Volume 4, Issue 4

· pp. 199–294 · 16 articles

In this issue

Forum Article
Treating Tuberculosis: Time to Introduce Fixed-Dose Drug Combinations
Manikandan S
pp. 199–200 · DOI: 10.4103/0975-1483.104362 · Published
Tuberculosis has been an elusive infectious disease. In India, two deaths occur every three minutes due to tuberculosis. As modern antituberculosis therapy (ATT) can cure all patients, these deaths can be prevented. But …

Article
Formulation and in vitro evaluation of floating tablets of hydroxypropyl methylcellulose and polyethylene oxide using ranitidine hydrochloride as a model drug
Gharti KP, Thapa P, Budhathoki U, Bhargava A
pp. 201–208 · DOI: 10.4103/0975-1483.104363 · Published
The present study was carried out with an objective of preparation and in vitro evaluation of floating tablets of hydroxypropyl methyl cellulose (HPMC) and polyethylene oxide (PEO) using ranitidine hydrochloride as a mod…
Article
Flurbiprofen-Loaded Stealth Liposomes: Studies on the Development, Characterization, Pharmacokinetics, and Biodistribution
Begum XY, Abbulu K, Sudhakar M
pp. 209–219 · DOI: 10.4103/0975-1483.104364 · Published
Flurbiprofen (FP) is a phenyl alkanoic acid derivative and a family of non-steroidal anti-inflammatory drug used in the treatment of arthritis. The aim of this study was to prepare a new parenteral formulation for FP tha…
Article
Studies on the Preparation, Characterization, and Solubility of 2-HP-B-Cyclodextrin-Meclizine HCI Inclusion Complexes
George SJ, Vasudevan DT
pp. 220–227 · DOI: 10.4103/0975-1483.104365 · Published
Meclizine HCl is a poorly water-soluble drug having a very slow-onset of action. The effect of 2-hydroxypropyl-ẞ-cyclodextrins and ẞ-cyclodextrins on its aqueous solubility and dissolution rate was investigated. The phas…

Article
Antioxidant and Hepatoprotective Activities of Ethanolic Extracts of Leaves of Premna esculenta Roxb. against Carbon Tetrachloride-Induced Liver Damage in Rats
Mahmud ZA, Bachar SC, Qais N
pp. 228–234 · DOI: 10.4103/0975-1483.104366 · Published
Premna esculenta Roxb. (family Verbenaceae) is a shrub used by the ethnic people of Chittagong Hill Tracts of Bangladesh for the treatment of hepatocellular jaundice. The present study was done to evaluate the hepatoprot…

Article
Antidepressant Potential of 5-HT3 Receptor Antagonist, N-n- propyl-3-ethoxyquinoxaline-2-carboxamide (6n)
Mahesh R, Bhatt S, Devadoss T, Jindal AK, Gautam BK, Pandey DK
pp. 235–244 · DOI: 10.4103/0975-1483.104367 · Published
The present study was designed to evaluate the antidepressant potential of 5-HT3 receptor antagonist N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n). The compound '6n' with optimum log P and pA, value identified from a…
Article
Efficacy of Extrinsic Stain Removal by Novel Dentifrice Containing Papain and Bromelain Extracts
Chakravarthy PK, Acharya S
pp. 245–249 · DOI: 10.4103/0975-1483.104368 · Published
To evaluate the stain removal efficacy of a novel dentifrice containing papain and bromelain extracts (Glodent) in comparison with a control dentifrice (Colgate regular). This was a randomized, positive-controlled, doubl…
Article
Association between Medication Adherence Outcomes and Adverse Drug Reactions to Highly Active Antiretroviral Therapy in Indian Human Immunodeficiency Virus-Positive Patients
Rajesh R, Sudha V, Varma DM, Sonika S
pp. 250–260 · DOI: 10.4103/0975-1483.104369 · Published
In India, interruptions to highly active antiretroviral therapy (HAART) are due to adverse drug reactions. This study was aimed to assess the association between HAART adherence and adverse drug reactions (ADRs) in human…

Article
A Bioinformatics Approach for Homology Modeling and Binding Site Identification of Triosephosphate Isomerase from Plasmodium falciparum 3D7
Ullah M, Hira J, Ghosh T, Ishaque N, Absar N
pp. 261–266 · DOI: 10.4103/0975-1483.104370 · Published
Malaria is a major public health concem, and malarial parasites have developed resistance against the commonly available drugs. So now a days it is a major concem to find out a new target for drug therapy. Plasmodium fal…

Article
Identifying Errors in Handwritten Outpatient Prescriptions in Oman
Nadiya MS Al Shahaibi,, Lamya S Al Said, Kini TG, Chitme HR
pp. 267–272 · DOI: 10.4103/0975-1483.104371 · Published
To evaluate and analyze the handwritten outpatient prescriptions and associated error of omissions from four different hospitals in Oman. The study designed was an observational, retrospective and analysis of prescriptio…
Article
Assessment of Medication-Related Problems in Geriatric Patients of a Rural Tertiary Care Hospital
Ramanath KV, Nedumballi S
pp. 273–278 · DOI: 10.4103/0975-1483.104372 · Published
Total world population consists 21% of geriatric population, and the 1991 census report shows that there are 57 millions in India. The high rate chronic problems of elderly patients attributes to various drug-related pro…
Article
Hospital Nuclear Pharmacy Survey: Preliminary Aspects in Brazil
Marcelo Pau Brasil, Marcio Paes de Barros, Leila Jorge Antunes, Ralph Santos-Oliveira
pp. 279–281 · DOI: 10.4103/0975-1483.104373 · Published
Radiopharmaceuticals are special drugs that in the composition preserve one or more radionuclides which can be used as diagnostic or therapeutic tools in Nuclear Medicine Units. This study evaluated hospitals and clinics…

Article
Pharmaceutical Care: Need of the Hour in India
Tumkur A, Muragundi PM, Shetty R, Naik A
pp. 282–286 · DOI: 10.4103/0975-1483.104374 · Published
Pharmaceutical care signifies a shift of practice in pharmacy from being drug product-oriented to the one that is patient-oriented to achieve definite outcomes that improves patients' quality of life. In order to achieve…

Communication
Gene Polymorphism in Amlodipine Induced Gingival Hyperplasia: A Case Report
Charles N, Ramesh V, Kennedy Babu SPK, Premalatha B
pp. 287–289 · DOI: 10.4103/0975-1483.104375 · Published
The management of cardiovascular disorders poses a dilemma for the medical fraternity. Calcium channel blockers are one of the most commonly used drugs for the management of this disorder, and it is also a well known fac…

Article
Author Index, 2012
Babar Z
pp. 290–290 · DOI: · Published
Charles N, Ramesh V, Premalatha B, Singh S. Gene polymorphism in amlodipine induced gingival hyperplasia: A case report.

Article
Title Index, 2012
Shahid KM
pp. 293–294 · DOI: · Published
A bioinformatics approach for homology modeling and binding site identification of triosephosphate isomerase from Plasmodium falciparum 3D7.