jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Pharmacognosy CommunicationsNOW IN
Article

Triterpenoids from Grewia plagiophylla K. Schum

Peter Muchoki Githinji1, Jeremiah Waweru Gathirwa2★, Margret Mwihaki Ng’ang’a1, Alex King’ori Machocho1★ Corresponding author

  1. 1Department of Chemistry, Kenyatta University, Nairobi, KENYA.
  2. 2Kenya Medical Research Institute, Centre for Traditional Medicine and Drug Research, Nairobi, KENYA.

CORRESPONDENCE

Jeremiah Waweru Gathirwa

Kenya Medical Research Institute, Centre for Traditional Medicine and Drug Research, Nairobi, KENYA.

jgathirwa@yahoo.com

Volume 10, Issue 3 · pp. 130–133 · PUBLISHED · DOI: 10.5530/pc.2020.3.25

View on PC original site ↗

ABSTRACT

Introduction: Plants of the genus Grewia have been used as medicinal agents to treat several diseases. Grewia species are reported in use as folk medicine for the treatment of malaria, diarrhoea, dysentery, typhoid fever, small pox, cough, irritable condition of intestine and bladder among others. Methods: The stem back material of Grewia plagiophylla was extracted using CH2Cl2: MeOH (1:1). Fractionation and Isolation of the extract was done using column chromatography with silica gel and eluting with hexaneethyl acetate solvent system in increasing polarity. The structures of the isolated compounds were elucidated on the basis of NMR experiments and the comparison of their spectroscopic data with literature values. Results: Studies on bioactive components of the stem back of Grewia plagiophylla led to isolation of three triterpenoids: stigmasterol (I), butelin (II) lup-20(29)-en-3-ol (III). The triterpenoids have been isolated for the first time from this species with compound (III) being reported for the first time from the genus of Grewia. The isolated compounds showed varying degrees of in vitro antimalarial activity against Plasmodium falciparum chloroquine-sensitive D6 and chloroquine-resistance W2 strains with significant cytotoxic activity against Vero cells.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Githinji, P. M., Gathirwa, J. W., Ng’ang’a, M. M., & Machocho, A. K. (). Triterpenoids from Grewia plagiophylla K. Schum. Pharmacognosy Communications, 10(3), 130–133. https://doi.org/10.5530/pc.2020.3.25