jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Pharmacognosy CommunicationsNOW IN
Article

Podocarpus elatus R.Br. Leaf Extracts are Ineffective Inhibitors of the Growth of a Panel of Bacterial Pathogens

Lindiwe Mpala1, Getmore Chikowe1, Ian Cock1,2★★ Corresponding author

  1. 1School of Environment and Science, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.
  2. 2Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

CORRESPONDENCE

Ian Cock

School of Environment and Science, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

i.cock@griffith.edu.au

Received: 05-09-2023; Revised: 12-11-2023; Accepted: 21-12-2023.

Volume 14, Issue 1 · pp. 34–40 · PUBLISHED · DOI: 10.5530/pc.2024.1.5

View on PC original site ↗

ABSTRACT

Introduction: Closely related plant species often share similar secondary metabolites and bioactivities and are therefore good targets for bioactivity testing when one or more species within a genus are known to possess therapeutic properties. The genus Podocarpus has a long history of medicinal usage in many areas of the world. Many species are known to have therapeutic properties, several species of which have well established antibacterial bioactivities. Materials and Methods: The ability of P. elatus leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results:The P. elatus methanolic and aqueous extracts were ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria and were nontoxic in the Artemia lethality assay following 24 hr exposure.Conclusion:Despite its reported therapeutic uses against other diseases and its close taxonomic relationship with several bioactive Podocarpus spp. with antibacterial activity, P. elatus leaf extracts were ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, fungi, virus and tumour cells is required.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Mpala, L., Chikowe, G., & Cock, I. (). Podocarpus elatus R.Br. Leaf Extracts are Ineffective Inhibitors of the Growth of a Panel of Bacterial Pathogens. Pharmacognosy Communications, 14(1), 34–40. https://doi.org/10.5530/pc.2024.1.5