Antiasthmatic effects of schizandrae fructus extract in mice with asthma
Hyungwoo Kim2, Yong‑Tae Ahn3, Youn Sook Kim4, Su In Cho5, Won Gun An5★★ Corresponding author
- 1Associate Professor.
- 2Department of Biomedical Science, Kyungdong University, Goseong‑gun, Gangwon‑do, South Korea.
- 3Master of Science.
- 4Professor, School of Korean Medicine, Pusan National University, Pusan.
Received: 25-04-2013; Revised: 01-05-2013.
Volume 10, Issue 37S · pp. S80–S85 · PUBLISHED 21 February 2014 · DOI: 10.4103/0973-1296.127348
ABSTRACT
Background: Schizandrae fructus (SF), the fruit of Schisandra chinensis, has been used for the treatment of cough, wheezing, dry mouth, hepatitis, cardiovascular disease, and as a tonic and astringent in China, Japan, and Korea. Objective: Investigation of the antiasthmatic effects of SF. Materials and Methods: We investigated the effects of SF on airway hyperresponsiveness (AHR) to methacholine, production levels of antigen‑specific antibodies, and histopathological changes in the lung tissue in a mouse model (Balb/c) of asthma induced by repeated intranasal instillation of an antigen. Results: SF lowered AHR to methacholine (P < 0.05), antigen‑specific immunoglobulin E (IgE) level (P < 0.01), and immune cell infiltration in mice with asthma. Prednisolone (PD) effectively decreased AHR (P < 0.01), total antibody (P < 0.01) and IgE (P < 0.01) levels, and immune cell infiltration. SF and PD did not affect the levels of antigen‑specific IgG1 and IgG2a antibodies. Conclusion: Our data suggest that SF has possible application as an antiasthmatic drug. We also suggest that SF could be used as a complementary or alternative medicine to glucocorticoids.
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Kim, H., Ahn, Y., Kim, Y. S., Cho, S. I., & An, W. G. (2014). Antiasthmatic effects of schizandrae fructus extract in mice with asthma. Pharmacognosy Magazine, 10(37S), S80–S85. https://doi.org/10.4103/0973-1296.127348