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Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues

Zahide Esra Durak1★, Süleyman Büber2, Erdinç Devrim2, Hilmi Kocaoğlu2, İlker Durak2★ Corresponding author

  1. 1Ordu University Centre Research Laboratory, Ordu, Turkey.
  2. 2Departments of Medical Biochemistry and, University Centre Research Laboratory, Ordu, Turkey.
  3. 3Surgical Oncology, Ankara University Faculty of Medicine, Ankara, Turkey.

CORRESPONDENCE

Zahide Esra Durak

Ordu University Centre Research Laboratory, Ordu, Turkey.

ilker_durak@yahoo.com

Received: 05-07-2013; Revised: 22-10-2013.

Volume 10, Issue 38S · pp. 214–216 · PUBLISHED 28 May 2014 · DOI: 10.4103/0973-1296.133232

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ABSTRACT

Objective: To investigate possible effects of aqueous taxus baccata extract on adenosine deaminase (ADA) activity in cancerous and noncancerous human tissues and to clarify mechanism(s) of its anticancer potential. Materials and Methods: Cancerous and noncancerous human gastric and colon tissues were used in the study. The extracts were prepared in distilled water. Before and after treatment with the extracts, ADA activities in the tissue homogenates were measured. Results: ADA activity was found to be higher in gastric tissue compared with colon tissue, but no differences were found between ADA activities of cancerous and noncancerous tissues for both as well. In the plant extract studies, it was found that taxus extract significantly inhibited ADA activity both in cancerous and noncancerous gastric and colon tissues. Conclusion: Our results suggest that aqueous extract from taxus baccata inhibits ADA activities in both gastric and colon tissues significantly. It is suggested that in addition to other proposed mechanisms, accumulated adenosine due to the inhibition of ADA enzyme might also play part in the anticancer properties of taxus species.

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    Durak, Z. E., Büber, S., Devrim, E., & Durak, H. K. L. (2014). Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues. Pharmacognosy Magazine, 10(38S), 214–216. https://doi.org/10.4103/0973-1296.133232