jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Pharmacognosy MagazineNOW IN
Article

Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its antiinflammatory, analgesic and antipyretic activities

Anant Kumar1★, Karishma Agarwal1★, Anil Kumar Maurya1, Karuna Shanker3, Umme Bushra3, Sudeep Tandon2, Dnyaneshwar U. Bawankule1★★ Corresponding author

  1. 1Department of Molecular Bioprospection, Biotechnology Division, Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India.
  2. 2Department of Process Chemistry and Technology, Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India.
  3. 3Department of Analytical Chemistry, Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India.

CORRESPONDENCE

Anant Kumar

Department of Molecular Bioprospection, Biotechnology Division, Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India.

du.bawankule@cimap.res.in

Received: 08-10-2014; Revised: 26-11-2014.

Volume 11, Issue 42S · pp. 217–224 · PUBLISHED 27 May 2015 · DOI: 10.4103/0973-1296.157743

View on PM original site ↗

ABSTRACT

Background: Long‑term use of nonsteroidal anti‑inflammatory drugs (NSAIDs) increases risk of having a range of gastrointestinal problems. Therefore, new anti‑inflammatory, analgesic, antipyretic drugs having lesser side effects are being searched all over the world as alternatives to NSAIDs. Aims: To evaluate the anti‑inflammatory, analgesic and antipyretic profile of Ocimum sanctum root extracts. Materials and Methods: Anti‑inflammatory profile of hexane (STH), chloroform (STC), ethyl acetate (STE), butanol (STB) and water (STW) extracts of OS was carried out by using carrageenan induced paw edema. STE a most active extract was further validated in dose dependent manner for anti‑inflammatory, analgesic and antipyretic activity as well as oral toxicity profile in small laboratory animals. Identification of bioactives flux and chemical signature of most active fraction STE was developed by using the high‑performance liquid chromatography fingerprinting. Results: An ethyl acetate fraction (STE) exhibit most potent anti‑inflammatory activity followed by STB, STW, STC and STH. Dose response study of STE showed anti‑inflammatory, analgesic and anti‑pyretic potential in dose‑dependent manner without any toxic effect at dose 2000 mg/kg. Chemical fingerprint revealed the presence of flavanoids. Conclusions: The present research revealed that STE possess anti‑inflammatory, analgesic and anti‑pyretic properties. However, future research is advocated to evaluate the pharmacological properties of isolated bioactive compounds.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Kumar, A., Agarwal, K., Maurya, A. K., Shanker, K., Bushra, U., Tandon, S., & Bawankule, D. U. (2015). Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its antiinflammatory, analgesic and antipyretic activities. Pharmacognosy Magazine, 11(42S), 217–224. https://doi.org/10.4103/0973-1296.157743