Nuclear Factor Kappa B Activation and Peroxisome Proliferator-activated Receptor Transactivational Effects of Chemical Components of the Roots of Polygonum multiflorum
Ya Nan Sun1, Wei Li2, Seok Bean Song3, Xi Tao Yan4, Seo Young Yang4, Young Ho Kim4★★ Corresponding author
- 1College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
- 2School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Korea.
- 3Gyeongbuk Institute for Bio-industry, Andong City, Gyeongbuk 760-380, Korea.
- 4College of Pharmacy, Korea University, Sejong 339-700, Korea.
CORRESPONDENCE
Young Ho Kim
College of Pharmacy, Korea University, Sejong 339-700, Korea.
Volume 12, Issue 45 · pp. 31–5 · PUBLISHED 2016 · DOI: 10.4103/0973-1296.176019
ABSTRACT
Background: Polygonum multiflorum is well-known as “Heshouwu” in traditional Chinese herbal medicine. In Northeast Asia, it is often used as a tonic to prevent premature aging of the kidney and liver, tendons, and bones and strengthening of the lower back and knees. Objective: To research the anti-inflammatory activities of components from P. multiflorum. Materials and Methods: The compounds were isolated by a combination of silica gel and YMC R-18 column chromatography, and their structures were identified by analysis of spectroscopic data (1D, 2D-nuclear magnetic resonance, and mass spectrometry). The anti-inflammatory activities of the isolated compounds 1−15 were evaluated by luciferase reporter gene assays. Results: Fifteen compounds (1–15) were isolated from the roots of P. multiflorum. Compounds 1−5 and 14−15 significantly inhibited tumor necrosis factor-α-induced nuclear factor kappa B-luciferase activity, with IC50 values of 24.16–37.56 µM. Compounds 1−5 also greatly enhanced peroxisome proliferator-activated receptors transcriptional activity with EC50 values of 18.26−31.45 μM. Conclusion: The anthraquinone derivatives were the active components from the roots of P. multiflorum as an inhibitor on inflammation-related factors in human hepatoma cells. Therefore, we suggest that the roots of P. multiflorum can be used to treat natural inflammatory diseases.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Sun, Y. N., Li, W., Song, S. B., Yan, X. T., Yang, S. Y., & Kim, Y. H. (2016). Nuclear Factor Kappa B Activation and Peroxisome Proliferator-activated Receptor Transactivational Effects of Chemical Components of the Roots of Polygonum multiflorum. Pharmacognosy Magazine, 12(45), 31–5. https://doi.org/10.4103/0973-1296.176019