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Article

Obtaining a Dry Extract from the Mikania laevigata Leaves with Potential for Antiulcer Activity

Mariana Viana Pinto1, Ezequiane Machado Oliveira1, Jose Luiz Rodrigues Martins2, Jose Realino de Paula1, Elson Alves Costa2, Edemilson Cardoso da Conceição1, Maria Teresa Freitas Bara1★★ Corresponding author

  1. 1Universidade Federal de Goiás, Faculdade de Farmácia-Laboratório de Pesquisa em Produtos Naturais-Goiânia–Goiás. Brazil, Brazil.
  2. 2Universidade Federal de Goiás, Instituto de Ciências Biológicas-Laboratório de Farmacologia de Produtos Naturais–Goiânia, Goiás. Brazil, Brazil.

CORRESPONDENCE

Maria Teresa Freitas Bara

Universidade Federal de Goiás, Faculdade de Farmácia-Laboratório de Pesquisa em Produtos Naturais-Goiânia–Goiás. Brazil, Brazil.

mtbara@gmail.com

Received: 03-02-2016; Revised: 23-03-2016; Accepted: 23-03-2016.

Volume 13, Issue 49 · pp. 76–80 · PUBLISHED 6 January 2017 · DOI: 10.4103/0973-1296.197640

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ABSTRACT

Background: Mikania laevigata leaves are commonly used in Brazil as a medicinal plant. Objective: To obtain hydroalcoholic dried extract by nebulization and evaluate its antiulcerogenic potential. Materials and Methods: Plant material and hydroalcoholic extract were processed and analyzed for their physicochemical characteristics. A method using HPLC was validated to quantify coumarin and o-coumaric acid. Hydroalcoholic extract was spray dried and the powder obtained was characterized in terms of its physicochemical parameters and potential for antiulcerogenic activity. Results: The analytical method proved to be selective, linear, precise, accurate, sensitive, and robust. M. laevigata spray dried extract was obtained using colloidal silicon dioxide as adjuvant and was shown to possess 1.83 ± 0.004% coumarin and 0.80 ± 0.012% o-coumaric acid. It showed significant antiulcer activity in a model of an indomethacin-induced gastric lesion in mice and also produced a gastroprotective effect. Conclusion: This dried extract from M. laevigata could be a promising intermediate phytopharmaceutical product.

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    Pinto, M. V., Oliveira, E. M., Martins, J. L. R., Paula, J. R. D., Costa, E. A., Conceição, E. C. D., & Bara, M. T. F. (2017). Obtaining a Dry Extract from the Mikania laevigata Leaves with Potential for Antiulcer Activity. Pharmacognosy Magazine, 13(49), 76–80. https://doi.org/10.4103/0973-1296.197640