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Article

Decoction of Dictamnus Dasycarpus Turcz. Root Bark Ameliorates Skin Lesions and Inhibits Inflammatory Reactions in Mice with Contact Dermatitis

Beodeul Yang1, Hong-Bum Lee2, Sura Kim3, Young Chul Park3, Koanhoi Kim3, Hyungwoo Kim3★★ Corresponding author

  1. 1Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam, Korea.
  2. 2Department of Microbiology and Immunology, School of Medicine, Pusan National University, Gyeongnam, Korea.
  3. 3Department of Pharmacology, School of Medicine, Pusan National University, Gyeongnam, Korea.

CORRESPONDENCE

Hyungwoo Kim

Department of Pharmacology, School of Medicine, Pusan National University, Gyeongnam, Korea.

kronos7@pusan.ac.kr

Received: 25-07-2016; Revised: 08-09-2016; Accepted: 08-09-2016.

Volume 13, Issue 51 · pp. 483–7 · PUBLISHED 19 July 2017 · DOI: 10.4103/0973-1296.211034

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ABSTRACT

Background: The root bark of Dictamnus dasycarpus Turcz. (Dictamni Radicis Cortex) has been widely used to treat skin diseases in Korea, and its anti-inflammatory efficacies were recently reported. Objective: The paper aims to investigate the inhibitory effects of decoction of Dictamni Radicis Cortex (DDRC) in mice with contact dermatitis (CD). Materials and Methods: We investigated the effects of DDRC on skin lesion characteristics such as crust, scales, incrustation and petechiae, the erythema and melanin indexes, skin thickness, histopathologic changes, and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced CD mice. Results: Topical application of DDRC ameliorated crust, scales, incrustation, and induced by DNFB. In addition, DDRC lowered the erythema index significantly (P < 0.05). DDRC effectively inhibited enlargement of skin thickness (P < 0.05). Histopathologic observation showed that DDRC inhibited epidermal hyperplasia, hyperkeratosis, and spongiotic changes. Finally, DDRC decreased production levels of IFN-γ, TNF-α and IL-6 induced by repeated application of DNFB (P < 0.05). Conclusion: These data suggest that DDRC can be used in the treatment of inflammatory skin diseases including CD. Moreover, these results are closely related to the decreasing production of TNF-α IFN-γ and IL-6 in inflamed tissues.

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    Yang, B., Lee, H., Kim, S., Park, Y. C., Kim, K., & Kim, H. (2017). Decoction of Dictamnus Dasycarpus Turcz. Root Bark Ameliorates Skin Lesions and Inhibits Inflammatory Reactions in Mice with Contact Dermatitis. Pharmacognosy Magazine, 13(51), 483–7. https://doi.org/10.4103/0973-1296.211034