jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Pharmacognosy MagazineNOW IN
Article

Naphthazarins as Cytotoxic Agents isolated from Arnebia euchroma

Nidhi Sharma2,3★, Ashu Gulati3, Dharmesh Kumar4, Yogendra Padwad4★ Corresponding author

  1. 1Academy of Scientific and Innovative Research (AcSIR), CSIR-Central Road Research Institute, Delhi-Mathura Road, CRRI, New Delhi, India.
  2. 2Food and Nutraceuticals Division, Natural Product Chemistry Lab, CSIR‑Institute of Himalayan Bioresource Technology, India.
  3. 3Food and Nutraceuticals Division, Pharmacology and Toxicology Lab, CSIR‑Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India.

CORRESPONDENCE

Nidhi Sharma

Food and Nutraceuticals Division, Natural Product Chemistry Lab, CSIR‑Institute of Himalayan Bioresource Technology, India.

sharma_12dec@rediffmail.com

Received: 14-03-2019; Revised: 18-05-2019.

Volume 15, Issue 64S · pp. S366–S370 · PUBLISHED 26 August 2019 · DOI: 10.4103/pm.pm_115_19

View on PM original site ↗

ABSTRACT

Background: Currently, many compounds of different medicinal plants are under investigation for curing various types of cancers. In extension with this ongoing research, Arnebia euchroma is taken for the study of cytotoxic compounds present in its roots. The sensitivity of human cervical cancer (SiHa), human epidermoid carcinoma (KB), and human colorectal cancer 116 (HCT116) cell lines toward C1 and C2 isolated from A. euchroma roots was evaluated. Materials and Methods: The root extract of A. euchroma was subjected to extraction, chromatographic separation to afford two naphthazarin esters C1 and C2 as well as two white‑colored compounds. The structures of purified compounds were determined by electrospray ionization mass spectrometry and nuclear magnetic resonance analysis. Results: Both C1 and C2 showed potent cytotoxicity against SiHa, KB, HCT116 cells at different concentrations. Conclusion: C1 and C2 exhibited strong cytotoxicity with IC50 = 0.02 µM and 0.09 µM against SiHa cells and with IC50 = 0.11 µM HCT116 cells than the vinblastine standard, respectively.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Sharma, N., Gulati, A., Kumar, D., & Padwad, Y. (2019). Naphthazarins as Cytotoxic Agents isolated from Arnebia euchroma. Pharmacognosy Magazine, 15(64S), S366–S370. https://doi.org/10.4103/pm.pm_115_19