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Article

Modulation of Sodium Arsenite-Induced Toxicity in Mice by Ethanolic Seed Extract of Trigonella foenum graecum

Surjyo Jyoti Biswas1★, Goutam Ghosh2, Ved Prakash Dubey3★ Corresponding author

  1. 1Department of Zoology, Sidho‑Kanho‑Birsha University, Purulia, India.
  2. 2Department of Zoology, Midnapore College, Midnapore, West Bengal, India.
  3. 3Department of Zoology, Government Naveen College, Katekalyan, Dakshin Bastar, Dantewada, Chhattisgarh, India.

CORRESPONDENCE

Surjyo Jyoti Biswas

Department of Zoology, Sidho‑Kanho‑Birsha University, Purulia, India.

surjyo@rediffmail.com

Received: 20-10-2018; Revised: 01-12-2018; Accepted: 12-03-2019.

Volume 15, Issue 66S · pp. S386–S395 · PUBLISHED 28 November 2019 · DOI: 10.4103/pm.pm_518_18

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ABSTRACT

Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> L. is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present study was aimed to evaluate the anti-inflammatory and antioxidant activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) stem. Materials and Methods: The anti-inflammatory activity was evaluated using the carrageenan-induced rat paw edema model. The antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, and total phenolic content (TPC) determination. Results: MECQ showed significant anti-inflammatory activity in a dose-dependent manner. In the antioxidant assays, MECQ exhibited strong DPPH radical scavenging activity (IC50 = 45.23 μg/mL) and high FRAP value. The TPC was found to be 124.5 mg gallic acid equivalent/g of extract. Conclusion: The results suggest that <em>Cissus quadrangularis</em> possesses significant anti-inflammatory and antioxidant activities, which may be attributed to its phenolic content.

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    Biswas, S. J., Ghosh, G., & Dubey, V. P. (2019). Modulation of Sodium Arsenite-Induced Toxicity in Mice by Ethanolic Seed Extract of Trigonella foenum graecum. Pharmacognosy Magazine, 15(66S), S386–S395. https://doi.org/10.4103/pm.pm_518_18