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Article

Effect of Ethanolic Extract of Carica papaya Leaves and their Cytotoxicity and Apoptotic Potential in Human Ovarian Cancer Cell Lines‑ PA‑1

Priyadurairaj Priyadurairaj1, Palagati Rohith Kumar Reddy1, Palaniyandi Thiruvanavukkarasu1, Sindhu Rajesh1, Suganya Karunakaran1, Rajeswary Hari1★★ Corresponding author

  1. 1Department of Biotechnology, Dr. MGR Educational and Research Institute University, Chennai, Tamil Nadu, India.

CORRESPONDENCE

Rajeswary Hari

Department of Biotechnology, Dr. MGR Educational and Research Institute University, Chennai, Tamil Nadu, India.

rajihar@gmail.com

Received: 29-03-2020; Revised: 14-05-2020; Accepted: 11-08-2020.

Volume 16, Issue 5S · pp. S524–S530 · PUBLISHED 30 November 2020 · DOI: 10.4103/pm.pm_117_20

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ABSTRACT

Background: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) in experimental animal models. Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet granuloma models. The analgesic activity was evaluated using acetic acid-induced writhing and tail-flick models in mice. Results: MECQ (200 and 400 mg/kg) showed significant (P < 0.01) anti-inflammatory activity in both acute and chronic models. In the analgesic models, MECQ showed significant (P < 0.01) reduction in the number of writhes and increased the reaction time in the tail-flick model. Conclusion: The results suggest that MECQ possesses significant anti-inflammatory and analgesic activities, which supports its traditional use in the treatment of inflammatory conditions and pain.

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    Priyadurairaj, P., Reddy, P. R. K., Thiruvanavukkarasu, P., Rajesh, S., Karunakaran, S., & Hari, R. (2020). Effect of Ethanolic Extract of Carica papaya Leaves and their Cytotoxicity and Apoptotic Potential in Human Ovarian Cancer Cell Lines‑ PA‑1. Pharmacognosy Magazine, 16(5S), S524–S530. https://doi.org/10.4103/pm.pm_117_20