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Pharmacognosy MagazineNOW IN
Article

Dietary Supplementation of Hemidesmus indicus and Swimming Exercise Attenuates Oxidative Stress in the Rat Brain

Bhagyalakshmi Dundaiah1★, Anupama Sindhaghatta Kariyappa1, Sowbhagya Ramachandregowda2, Santosh Anand1★ Corresponding author

  1. 1Ravikiran Tekupalli Department of Biotechnology, Bangalore University, India.
  2. 2Department of Biotechnology and Genetics, Ramaiah College of Arts Science and Commerce, Bengaluru, Karnataka, India.

CORRESPONDENCE

Bhagyalakshmi Dundaiah

Ravikiran Tekupalli Department of Biotechnology, Bangalore University, India.

ravikiran@bub.ernet.in

Received: 02-06-2019; Revised: 26-08-2019; Accepted: 20-08-2019.

Volume 16, Issue 67 · pp. 21–26 · PUBLISHED 11 February 2020 · DOI: 10.4103/pm.pm_239_19

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ABSTRACT

Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em>. Materials and Methods: The methanolic extract of <em>C. arnottiana</em> leaves was evaluated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide, and hydroxyl radical scavenging assays. Anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. Results: The extract showed significant antioxidant activity in a dose-dependent manner. In the anti-inflammatory assay, the extract at 200 and 400 mg/kg doses significantly reduced paw edema compared to the control group. Conclusion: <em>C. arnottiana</em> possesses significant antioxidant and anti-inflammatory activities, supporting its traditional use.

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    Dundaiah, B., Kariyappa, A. S., Ramachandregowda, S., & Anand, S. (2020). Dietary Supplementation of Hemidesmus indicus and Swimming Exercise Attenuates Oxidative Stress in the Rat Brain. Pharmacognosy Magazine, 16(67), 21–26. https://doi.org/10.4103/pm.pm_239_19