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Article

Effects of Anacyclus pyrethrum on Affective Behaviors and Memory during Withdrawal from Cigarette Smoke Exposure in Rats

Kenza Bezza1★, Jawad Laadraoui2, Zineb El Gabbas2, Mehdi Ait Laaradia2, Sara Oufquir2, Rachida Aboufatima3, Issam Gharrassi4, Abederrahman Chait2★ Corresponding author

  1. 1Department of Biology, Laboratory of Pharmacology, Neurobiology and Behavior, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech.
  2. 2Laboratory of Biological Engineering, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Beni Mellal.
  3. 3Anatomic Pathology Services, Avicenna Military Hospital, Medical School Faculty, Cadi Ayyad University, Marrakech, Morocco.

CORRESPONDENCE

Kenza Bezza

Department of Biology, Laboratory of Pharmacology, Neurobiology and Behavior, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech.

kenzabezza@gmail.com

Received: 27-06-2019; Revised: 30-09-2019.

Volume 16, Issue 68S · pp. S123–S132 · PUBLISHED 31 March 2020 · DOI: 10.4103/pm.pm_279_19

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ABSTRACT

Objectives: The aim of this study was to evaluate the behavioral effects of ethanolic extract of A. pyrethrum (EEAP) on smoking withdrawal in a rat model. Subjects and Methods: EEAP was administered orally at a dose of 200, 400, and 800 mg/kg. Forced swimming test (FST), open‑field, marble‑burying, and plus‑maze tests were used to measure the level of depression and anxiety in animals. In addition, the novel object recognition test was used to test memory impairment. Results: The results showed that EEAP‑treated animals had decreased immobility time in forced swimming test and they buried fewer marbles. The percentage of the time spent and the number of entries in the open arm within the elevated plus‑maze test was increased in smoking withdrawn rat after treatment. On the other hand, EEAP increased the recognition of memory in the novel object recognition task. Conclusion: Taken together, our data indicated potential antidepressant‑like and anxiolytic‑like effects of EEAP in rats and the improvement of memory. Besides, this plant does not have any acute or subchronic toxicity effect.

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    Bezza, K., Laadraoui, J., Gabbas, Z. E., Laaradia, M. A., Oufquir, S., Aboufatima, R., Gharrassi, I., & Chait, A. (2020). Effects of Anacyclus pyrethrum on Affective Behaviors and Memory during Withdrawal from Cigarette Smoke Exposure in Rats. Pharmacognosy Magazine, 16(68S), S123–S132. https://doi.org/10.4103/pm.pm_279_19