Study on the Characteristics of Pharmacokinetics of Different Doses of Gastrodin in Mice
Xinyu Wang1, Xin Liu1, Xing Wang1★, Yu Dong1★ Corresponding author
- 1College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, China.
CORRESPONDENCE
Xing Wang
College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, China.
Received: 21-07-2019; Revised: 16-09-2019; Accepted: 17-02-2020.
Volume 16, Issue 69 · pp. 347–352 · PUBLISHED 15 June 2020 · DOI: 10.4103/pm.pm_307_19
ABSTRACT
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) in experimental animal models. Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model, and analgesic activity was assessed using acetic acid-induced writhing and hot plate methods in mice. Results: MECQ at doses of 200 and 400 mg/kg showed significant (P < 0.01) anti-inflammatory activity in carrageenan-induced rat paw edema. In analgesic models, MECQ exhibited significant (P < 0.01) reduction in the number of writhes in acetic acid-induced writhing test and increased the reaction time in hot plate method. Conclusion: The results suggest that MECQ possesses significant anti-inflammatory and analgesic activities, which supports its traditional use.
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Wang, X., Liu, X., Wang, X., & Dong, Y. (2020). Study on the Characteristics of Pharmacokinetics of Different Doses of Gastrodin in Mice. Pharmacognosy Magazine, 16(69), 347–352. https://doi.org/10.4103/pm.pm_307_19