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Behavioral and Physiological Assessments to Evaluate the Effect of Acacia senegal and Acacia seyal in Albino Mice

Gadah Albasher2★, Nahed S. Alharthi3, Saad Alkahtani2, Nada Aljarba4, Nouf Al Sultan2, Ahad A. Alsaiari5, Omaima Nasir6, May Bin-Jumah4, Wedad S. Alqahtani2★ Corresponding author

  1. 1Department of Zoology, College of Science, King Saud University, Saudi Arabia.
  2. 2Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Saatam bin Abdul Aziz University, Al-Kharj, Saudi Arabia.
  3. 3Department of Biology, College of Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
  4. 4Department of Clinical Laboratory Science, College of Applied Medical Sciences, Saudi Arabia.
  5. 5Department of Biology, Turabah College, Taif University, Taif, Saudi Arabia.

CORRESPONDENCE

Gadah Albasher

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Saatam bin Abdul Aziz University, Al-Kharj, Saudi Arabia.

galbeshr@ksu.edu.sa

Received: 15-02-2020; Revised: 28-03-2020; Accepted: 21-04-2020.

Volume 16, Issue 70S · pp. S410–S417 · PUBLISHED 28 August 2020 · DOI: 10.4103/pm.pm_20_20

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ABSTRACT

Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em>. Materials and Methods: The antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and total antioxidant capacity assays. The anti-inflammatory activity was evaluated using the protein denaturation inhibition assay and the membrane stabilization assay. Results: The methanolic extract of <em>Cissus arnottiana</em> showed significant antioxidant activity in all the tested models. The extract also exhibited significant anti-inflammatory activity by inhibiting protein denaturation and stabilizing the red blood cell membrane. Conclusion: The results suggest that <em>Cissus arnottiana</em> possesses significant antioxidant and anti-inflammatory properties, which could be attributed to the presence of phytochemicals such as flavonoids and phenolic compounds.

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    Albasher, G., Alharthi, N. S., Alkahtani, S., Aljarba, N., Sultan, N. A., Alsaiari, A. A., Nasir, O., Bin-Jumah, M., & Alqahtani, W. S. (2020). Behavioral and Physiological Assessments to Evaluate the Effect of Acacia senegal and Acacia seyal in Albino Mice. Pharmacognosy Magazine, 16(70S), S410–S417. https://doi.org/10.4103/pm.pm_20_20