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Pharmacognosy MagazineNOW IN
Article

Vernonia anthelmintica (L.) Willd Extract Alleviates Cognitive Deficits and Neurodegeneration Induced by Infusion of Amyloid Beta (1–42) in Rats

Swati Som1, Justin Antony2, S. Palanisamy Dhanabal3, Sivasankaran Ponnusankar1★★ Corresponding author

  1. 1Departments of Pharmacy Practice, College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamil Nadu, India.
  2. 2Pharmacology and, India.
  3. 3Pharmacognosy and Phytochemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamil Nadu, India.

CORRESPONDENCE

Sivasankaran Ponnusankar

Departments of Pharmacy Practice, College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamil Nadu, India.

ponnusankarsivas@gmail.com

Received: 02-12-2020; Revised: 05-01-2021; Accepted: 04-08-2021.

Volume 17, Issue 6S · pp. S172–S179 · PUBLISHED 15 September 2021 · DOI: 10.4103/pm.pm_518_20

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ABSTRACT

Objectives: The objective of the current investigation is to explore the neuroprotective activity of methanolic extract of V. anthelmintica (MEVA) in amyloid‑beta (Aβ) (1–42) infused sporadic model of AD. Materials and Methods: Adult healthy male Wistar rats were treated orally with 250 mg/kg and 500 mg/kg of MEVA for 28 days, after a week from intracerebroventricular (i.c.v) infusion of Aβ (1–42) peptides followed by assessment of neurobehavioral deficits. Subsequently, animals were euthanized and brains were collected for estimation and quantification of neurochemical biomarkers including antioxidant enzymes, neurotransmitters, plaque load, and inflammatory mediators. Results: Dose‑dependent reversal of cognitive impairment was observed upon MEVA treatment in amyloid intoxicated rats as corroborated by improved learning and memory and diminished oxidative stress, cholinergic hypofunction, and neuroinflammation induced by Aβ (1–42). Conclusion: Collectively, evidence‑based data suggested the promising neurotherapeutic potential of V. anthelmintica and thereby can stand as a novel entity for curbing AD pathology.

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    Som, S., Antony, J., Dhanabal, S. P., & Ponnusankar, S. (2021). Vernonia anthelmintica (L.) Willd Extract Alleviates Cognitive Deficits and Neurodegeneration Induced by Infusion of Amyloid Beta (1–42) in Rats. Pharmacognosy Magazine, 17(6S), S172–S179. https://doi.org/10.4103/pm.pm_518_20