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Pharmacognosy MagazineNOW IN
Article

Resveratrol Exerts Anti‑Inflammatory Effect in Lipopolysaccharide‑Induced Lung Inflammation via Downregulation of Antioxidant and Inflammatory Mediators

Xinxin Liang1★, Jian Shen1★, Xueming Duan1, Rongbing Zhou2, Peng Liu3, Xiaoming Chi4★★ Corresponding author

  1. 1Department of Pulmonary and Critical Care Medcine, Chengdu Institute of Respiratory Health,The Third People’s Hospital of Chengdu, Chengdu, Sichuan Province, China.
  2. 2Department of Intensive Medicine, The People’s Hospital of Guangrao, Dongying, Shandong Province, China.
  3. 3Department of Emergency, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
  4. 4Department of ICU, Affiliated Hospital of Weifang Medical College, WeiFang, Shandong Province, China.

CORRESPONDENCE

Xinxin Liang

Department of Pulmonary and Critical Care Medcine, Chengdu Institute of Respiratory Health,The Third People’s Hospital of Chengdu, Chengdu, Sichuan Province, China.

chixiaoming2019@sina.com

Received: 21-03-2020; Revised: 22-04-2020; Accepted: 12-03-2021.

Volume 17, Issue 74 · pp. 275–281 · PUBLISHED 12 July 2021 · DOI: 10.4103/pm.pm_41_20

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ABSTRACT

Objectives: In this study, the chemoprotective effect of resveratrol and its of mechanism of action against the Lipopolysaccharide (LPS)-induced lung inflammation was investigated. Materials and Methods: In this in vitro study, we performed experiments using RAW 264.7 cells. LPS was used to induce inflammation in the lungs of Swiss Wistar rats that were randomly divided into different groups. The rats were treated with resveratrol in a dose-dependent manner. The lung tissue and dry/wet weight of lung tissue was estimated. The antioxidant activity and anti-inflammatory parameters were also estimated. Results: According to results, resveratrol significantly reduced the secretion of pro-inflammatory cytokines including interleukin (IL)-1β, IL-4, IL-6, tumor necrosis factor-α (TNF-α), IL-18, IL-10, and antioxidant parameters viz., glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD), respectively. Resveratrol significantly (P<0.001) reduced the weight of lung tissue and dry/wet of lung tissue at dose-dependent manner. Conclusion: In summary, resveratrol plays the role of a chemo-protective agent against the LPS-induced lung inflammation via anti-inflammatory and antioxidant mechanism.

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    Liang, X., Shen, J., Duan, X., Zhou, R., Liu, P., & Chi, X. (2021). Resveratrol Exerts Anti‑Inflammatory Effect in Lipopolysaccharide‑Induced Lung Inflammation via Downregulation of Antioxidant and Inflammatory Mediators. Pharmacognosy Magazine, 17(74), 275–281. https://doi.org/10.4103/pm.pm_41_20