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Data Mining and Network Pharmacology Study on Dried Tangerine Peel and Immature Tangerine Peel Essential Oil as a Treatment for Liver Depression and Insomnia

Gang Ke1, Guilin Ren2, Qingrong Pu2, Rui Huang2, Ting Liu1, Lu Liu1, Qian Gong1, Jie Li1, Rong Li1★★ Corresponding author

  1. 1Department of Pharmacy, Luzhou People’s Hospital, China.
  2. 2Department of Pharmacy, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.

CORRESPONDENCE

Rong Li

Department of Pharmacy, Luzhou People’s Hospital, China.

1007866178@qq.com

Received: 18-12-2020; Revised: 13-05-2021; Accepted: 26-07-2021.

Volume 17, Issue 76 · pp. 684–694 · PUBLISHED 24 January 2022 · DOI: 10.4103/pm.pm_559_20

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ABSTRACT

Objectives: To study the mechanism of volatile oil in treating liver depression and insomnia. Materials and Methods: Through data mining, we found dried and immature tangerine peel as a prescription for treating liver depression and insomnia. Gas chromatography‑mass spectrometry was achieved to control the chemical composition of the essential oil. The effects of dried and immature tangerine peel essential oil on sleep latency and sleep duration were also explored using a pentobarbital‑induced sleep test in mice. Network pharmacology tactics was executed to determine the potential active ingredients and molecular mechanism of the dried and immature tangerine peel essential oil in treating liver depression and insomnia. Results: Dried and immature tangerine peel essential oil has both calming and tranquilizing effects. Based on the network pharmacology, it was foretold that essential oil were mostly employed to treat liver depression and insomnia with predicted functions convoluted in regulating several neurotransmitters, such as the gamma‑aminobutyric acid in the neuroactive receptor‑ligand signaling pathway. Conclusion: In this study, the effect of volatile oil from dried tangerine peel and immature tangerine peel on mice sleep was established, and the mechanism of action for treating liver depression and insomnia was preliminarily deliberated.

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    Ke, G., Ren, G., Pu, Q., Huang, R., Liu, T., Liu, L., Gong, Q., Li, J., & Li, R. (2022). Data Mining and Network Pharmacology Study on Dried Tangerine Peel and Immature Tangerine Peel Essential Oil as a Treatment for Liver Depression and Insomnia. Pharmacognosy Magazine, 17(76), 684–694. https://doi.org/10.4103/pm.pm_559_20