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Article

Antidepressant Effect of Buddleja cordata Methanolic Extract in Chronic Stress Mouse Model

Griselda García-Alonso2★, Marco Atzori3, Roberto Salgado3, Adrian Báez3, Marcela Miranda3, Aylin Rangel3, Edgar Guevara3,4, Roberto Cuevas3, José Manuel Vega-Riquer2, José Guillermo Avila-Acevedo5, Antonio Monroy-Noyola6★ Corresponding author

  1. 1Medicine School, Universidad del Valle de México, Saltillo Coahuila.
  2. 2Science Faculty, Universidad Autónoma de San Luis Potosí.
  3. 3Coordination for Innovation and application of Science and Technology, Universidad Autónoma de San Luis Potosí, SLP.
  4. 4Phytochemistry laboratory UBIPRO, Faculty of higher education, Universidad Nacional Autónoma de México, Ciudad de México.
  5. 5Pharmacy Faculty, Universidad Autónoma del Estado de Morelos, Morelos, México.

CORRESPONDENCE

Griselda García-Alonso

Science Faculty, Universidad Autónoma de San Luis Potosí.

amonroy@uaem.mx

Received: 31-12-2020; Revised: 22-04-2021; Accepted: 21-05-2021.

Volume 17, Issue 76 · pp. 780–785 · PUBLISHED 24 January 2022 · DOI: 10.4103/pm.pm_554_20

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ABSTRACT

Objectives: To explore the antidepressant effect of a methanolic extract of Buddleja cordata leaves (MEBc) in early maternal separation and chronic restraint stress mouse model. Materials and Methods: From day 2 to day 21, the litters were removed from the maternal cage for 3h/day. Based on the pharmacological treatments, four experimental groups were established: sham animals without maternal separation, chronic restrained stress and oral administration (S group) or 10 ml/Kg/day saline solution (SS group) or 100 mg/kg/day of MEBc (MEBc group) or 20 mg/kg/day of fluoxetine (F group). After 4 weeks of these treatments the antidepressant activity was evaluated through behavioral tests and also IL-6 determinations were performed. Results: Mice administered with MEBc showed significantly diminished immobility time in the forced swimming test (P < 0.01), tail suspension test (P < 0.001) and the time spent in the open arm of the elevated plus- maze (P < 0.01) versus SS group. By contrast, animals treated with fluoxetine only diminished immobility time in the tail suspension test (P < 0.01). The vegetal extract was more effective (P < 0.05) that fluoxetine in preventing the increase of interleukin 6 (IL-6) over the hippocampus and prefrontal cortex region (45 and 20 %, respectively). Conclusion: These results demonstrate the antidepressant and anxiolytic effects of MEBc over the chronic stress depression-induced model.

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    García-Alonso, G., Atzori, M., Salgado, R., Báez, A., Miranda, M., Rangel, A., Guevara, E., Cuevas, R., Vega-Riquer, J. M., Avila-Acevedo, J. G., & Monroy-Noyola, A. (2022). Antidepressant Effect of Buddleja cordata Methanolic Extract in Chronic Stress Mouse Model. Pharmacognosy Magazine, 17(76), 780–785. https://doi.org/10.4103/pm.pm_554_20