Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci and tumors in the rat colon by resveratrol
Sengottuvelan M1, Nalini N1★★ Corresponding author
- 1Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India.
CORRESPONDENCE
Nalini N
Nalini. N,Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India.
Volume 2, Issue 5 · pp. 42–43 · PUBLISHED 2006 · DOI:
ABSTRACT
The purpose of the present study was to investigate the effect of resveratrol (RES) on 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. The numbers of colon tumors and the formation of aberrant crypt foci (ACF), a premalignant lesion in rats were significantly reduced on resveratrol (8 mg/kg body weight) supplementation. Moreover, resveratrol supplementation for the entire treatment period showed significantly better chemopreventive activity against DMH-induced rat colon carcinogenesis as compared to resveratrol supplementation during the initiation and post-initiation stages of carcinogenesis.
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M, S., & N, N. (2006). Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci and tumors in the rat colon by resveratrol. Pharmacognosy Magazine, 2(5), 42–43.