Anticholesterolemic, Hepatoprotective and Antioxidant activity of Glinus lotoides linn. against ethanol induced liver damage in rats
Sathiyanarayanan. L1, Arulmozhi. S2★, Chidambaranathan. N3★ Corresponding author
- 1Department of Pharmaceutical Chemistry, Oxford College of Pharmacy, J.P Nagar I Phase, Bangalore – 560 078, India.
- 2Department of Pharmacology, K.L.E.S’s College of Pharmacy, Rajaji Nagar II Block,Bangalore – 560 010, India.
- 3Department of Pharmacology, K.M. College of Pharmacy, Uthangudi, Madurai – 625 107, India.
CORRESPONDENCE
Arulmozhi. S
Department of Pharmacology, K.L.E.S’s College of Pharmacy, Rajaji Nagar II Block,Bangalore – 560 010, India.
Volume 2, Issue 7 · pp. 160–162 · PUBLISHED 2006 · DOI:
ABSTRACT
The aim of the present study was to investigate the effect of ethanolic extract of Glinus lotoides Linn. (EEGL) against ethanol induced lipid peroxidation. Administration of ethanol (18%) for 45 days induces lipid peroxidation leading to liver damage. Hence the enzyme levels such AST, which are good markers of liver condition have been elevated and also the triglycerides and cholesterol. Simultaneous administration of EEGL at the dose of 200 mg/kg and 400 mg/kg reduced these elevated parameters significantly (p<0.001) substantiating that EEGL is inhibiting the ethanol induced liver damage in rats. This was further supported by the evidence of significantly increased (p<0. 05, p<0.01 respectively) glutathione level indicating increased antioxidant enzyme level and significantly (p<0.001) decreased malondialdehyde level indicating the decreased oxidative stress.
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L, S., S, A., & N, C. (2006). Anticholesterolemic, Hepatoprotective and Antioxidant activity of Glinus lotoides linn. against ethanol induced liver damage in rats. Pharmacognosy Magazine, 2(7), 160–162.