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Ginsenoside CK Induces the Mitochondrial Apoptosis in Glioma Cells through the Activation of the p53-Bax-Caspase Pathway

Yang Bai1, Yuanhao Liu1, Lihao Lin1, Xinze Liu2, Xilin Wan2, Xinmin Wu1★★ Corresponding author

  1. 1Department of Neurosurgery, First Hospital of Jilin University, Changchun, CHINA.
  2. 2Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China.

CORRESPONDENCE

Xinmin Wu

Department of Neurosurgery, First Hospital of Jilin University, Changchun, CHINA.

wuxinmin@jlu.edu.cn

Received: 13-12-2022; Accepted: 02-06-2023.

Volume 20, Issue 2 · pp. 505–515 · PUBLISHED 2024 · DOI: 10.1177/09731296231203457

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ABSTRACT

Background: Gliomas are harmful to human health; they are the most common primary intracranial tumor. Ginsenoside CK (GS-CK) is converted from the diol ginsenoside. This study aimed to explore the effects of GS-CK on glioma cells SHG- 44 and U251MG in order to provide clinical value for the treatment of gliomas. Materials and Methods: Cell proliferation was detected using the CCK-8 and CFU detection experiments. Cell apoptosis was detected by DAPI and acridine orange/ethidium bromide (AO/EB) fluorescence staining. Cell scratch and transwell assay were used to detect the effect of GS-CK on cell migration and invasion ability. Apoptosis-related protein expression was detected in the two cell lines after treatment with GS-CK. Results: Cell proliferation is obviously inhibited, and cell migration and invasion were also significantly inhibited by GS-CK. It also induced cell apoptosis in a time- and dose-dependent manner. GS-CK induced significant changes in mitochondrial apoptosis pathway-related protein expression of cytochrome C, p53, Bax, Bcl-2, Caspase-3/8/9, Cleaved Caspase-3, and MMP-9 in glioma cells. Conclusion: GS-CK can inhibit glioma cells by regulating mitochondria-related apoptosis p53-bax-caspases pathway.

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    Bai, Y., Liu, Y., Lin, L., Liu, X., Wan, X., & Wu, X. (2024). Ginsenoside CK Induces the Mitochondrial Apoptosis in Glioma Cells through the Activation of the p53-Bax-Caspase Pathway. Pharmacognosy Magazine, 20(2), 505–515. https://doi.org/10.1177/09731296231203457