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Article

Effects of Motherwort on Biological Behavior of Brain Tissue in Rats with Ischemic Stroke and its Relationship with Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway

Guangyu Cao1, Jianju Zhou2, Guoqing Yu3, Xiaohong Fu3, Bo Xiong4★★ Corresponding author

  1. 1Department of Neurology, Zunyi First People’s Hospital, Zunyi, Guizhou, CHINA.
  2. 2Department of Neurological Rehabilitation, Zunyi First People’s Hospital, Zunyi, Guizhou, CHINA.
  3. 3Department of Neurosurgical Center-Cerebrovascular Disease, Zunyi First People’s Hospital, Zunyi, Guizhou, CHINA.
  4. 4Department of Cerebrovascular Diseases, Zunyi First People’s Hospital, Zunyi, Guizhou, CHINA.

CORRESPONDENCE

Bo Xiong

Department of Cerebrovascular Diseases, Zunyi First People’s Hospital, Zunyi, Guizhou, CHINA.

jiyi63420196518@126.com

Received: 31-07-2024; Accepted: 07-10-2024.

Volume 21, Issue 3 · pp. 1114–1123 · PUBLISHED 2025 · DOI: 10.1177/09731296241296204

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ABSTRACT

Background: Motherwort has a protective effect on the nervous system and can improve cerebral ischemia–reperfusion injury to a certain extent. However, the effect of motherwort on the biological behavior of the brain tissue of rats with ischemic stroke and its relationship with the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway is still unclear. Objectives: Therefore, we will explore the effect of motherwort on the biological behavior of the brain tissue of rats with ischemic stroke and its relationship with the PI3K/AKT signaling pathway. Materials and Methods: There were 17 model rats in each group, divided into a control group, a model group, and a motherwort (low, medium, and high) dose group. Detect cell proliferation, invasion, and so on, and observe the expression of proteins and genes such as nuclear factor kappa B (NF-κB), AKT, Pl3K, and β-actin. Results: After successfully constructing a rat model of ischemic stroke, motherwort can improve neurological damage and cerebral infarction in ischemic stroke and is closely related to PI3K/AKT signaling; in addition, motherwort can upregulate PI3K/AKT signaling and improve neurological damage and cerebral infarct size in ischemic stroke rats to a certain extent, and play a role in protecting neurons. Conclusion: The antioxidant and antineuronal apoptosis effects of motherwort can improve neurological damage and cerebral infarction area of ischemic stroke rats by upregulating the expression level of the PI3K/AKT signaling pathway, thereby inhibiting nerve cells. Apoptosis further protects neurons and plays a role in slowing down disease progression.

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    Cao, G., Zhou, J., Yu, G., Fu, X., & Xiong, B. (2025). Effects of Motherwort on Biological Behavior of Brain Tissue in Rats with Ischemic Stroke and its Relationship with Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway. Pharmacognosy Magazine, 21(3), 1114–1123. https://doi.org/10.1177/09731296241296204