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Article

Protective Effect of 1,8-Cineole (Eucalyptol) on Respiratory System: A Systematic Review and Meta-analysis from Animal Studies

Jie Liu1, Xingde Liu3, Xiaoman Xiong3, Yuhua Zheng3, Rui Rao4, Wen Li1★★ Corresponding author

  1. 1Department of Basic Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, CHINA.
  2. 2Department of Cardiology, Longli Hospital of Traditional Chinese Medicine, Qiannan, Guizhou, CHINA.
  3. 3Department of Cardiology, Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, CHINA.
  4. 4Department of Endocrinology, Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, CHINA.

CORRESPONDENCE

Wen Li

Department of Basic Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, CHINA.

liwen277@gzy.edu.cn

Received: 25-04-2024; Accepted: 07-10-2024.

Volume 21, Issue 4 · pp. 1220–1230 · PUBLISHED 2025 · DOI: 10.1177/09731296241296202

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ABSTRACT

Background: 1,8-Cineole is used in traditional folk medicine to treat various diseases. This study evaluates the protective effects of 1,8-cineole on the respiratory system by investigating its impact on inflammatory factors in animal studies. Materials and Methods: We conducted searches in PubMed, Medline, Embase, Cochrane, and the Web of Science databases until December 2023. This study utilized Get Data Graph Digitizer 2.26, EndNote, and RevMan 5.4. The random effects model and standard mean difference (SMD) were applied for data analysis. Results: The results showed tumor necrosis factor-alpha (TNF-α) (SMD: −8.19, 95% CI: −11.30 to −5.08, p < 0.00001), interleukin (IL)-6 (SMD: −7.38, 95% CI: −10.61 to −4.15, p < 0.00001), IL-1β (SMD: −19.18, 95% CI: −32.57 to −5.79, p = 0.005), NF-κB (SMD: −6.26, 95% CI: −7.88 to −4.65, p < 0.00001), neutrophils (SMD: −8.16, 95% CI: −11.65 to −4.67, p < 0.00001), and macrophages (SMD: −5.06, 95% CI: −8.06 to −2.05, p = 0.001). Conclusion: The study suggests that 1,8-cineole significantly inhibits the expression of inflammatory factors, indicating its potential for further study and development.

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    Liu, J., Liu, X., Xiong, X., Zheng, Y., Rao, R., & Li, W. (2025). Protective Effect of 1,8-Cineole (Eucalyptol) on Respiratory System: A Systematic Review and Meta-analysis from Animal Studies. Pharmacognosy Magazine, 21(4), 1220–1230. https://doi.org/10.1177/09731296241296202