Pimpinellin Abrogates Streptozotocin-induced Gestational Diabetes in Pregnant Rats Via Downregulating Inflammation and Oxidative Stress

ABSTRACT

Background: Gestational diabetes, defined by increased blood glucose levels during pregnancy, impacts a considerable proportion of pregnant women globally. The proper management of gestational diabetes is crucial, as it is connected with short- and long-term health consequences for both the mother and fetus. Objectives: This research work was devoted to addressing the beneficial roles of pimpinellin against streptozotocin (STZ)- induced gestational diabetic complications in the experimental rat model. Materials and Methods: Pregnant rats were treated with STZ to induce gestational diabetes, after which the gestational diabetes rats received pimpinellin treatment for 14 days. Upon completion of treatments, measurements were taken for body weight, blood glucose, and the survival and body weight of the pups. The levels of lipid profile markers, anti-oxidant concentrations, and proinflammatory cytokine levels were assessed utilizing commercial diagnostic kits. A histological examination was performed on the pancreas collected from the treated rats. Results: The findings of this work demonstrated that pimpinellin at 50 mg/kg concentration effectively lessened the glucose level and body weight of the gestational diabetes rats. The pimpinellin treatment also increased the survival of the pups. The treatment with pimpinellin successfully decreased inflammatory cytokines, regulated lipid profile biomarkers, and mitigated oxidative stress by increasing anti-oxidants in rats with gestational diabetes. The histopathological examination of the pancreas also validated the salutary properties of pimpinellin. Conclusion: The results of this work highlight that pimpinellin positively influences the reduction of gestational diabetes conditions and its associated complications in rats. Consequently, it possesses the potential to serve as an effective treatment alternative for managing gestational diabetes.

KEYWORDS

• Gestational diabetes
• hyperlipidemia
• hyperlipidemia
• oxidative stress
• pimpinellin

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• DOI10.1177/09731296251333261Copy

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