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Hypoglycemic and Anti-hyperglycemic Effect of Alcoholic Extract of Benincasa hispida in Normal and in Alloxan Induced Diabetic Rats

G. R. Battu1★, S. N. Mamidipalli1, R. Parimi1, R. K. Viriyala1, R. P. Patchula1, L. R. Mood1★ Corresponding author

  1. 1Pharmacognosy and Phytochemistry Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam- 530 003, India.

CORRESPONDENCE

G. R. Battu

Pharmacognosy and Phytochemistry Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam- 530 003, India.

sanjithmamidipalli@yahoo.co.in

Volume 3, Issue 10 · pp. 101–102 · PUBLISHED 2007 · DOI:

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ABSTRACT

The hypoglycemic and anti-hyperglycemic effect of alcoholic extract of Benincasa hispida was investigated in normal and alloxan induced diabetic rats. A single oral administration of alcoholic extract of Benincasa hispida at doses 50,100,200mg/kg produced a significant blood glucose reduction in a dose dependent manner. A bioguided extraction and fractionation of alcoholic extract of the stem of Benincasa hispida afforded three compounds, β-sitosterol, α-amyrin, quercetin. The alcoholic extract at 200mg/kg significantly reduced the blood glucose levels and equipotent with that of the standard drug Tolbutamide.

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    Battu, G. R., Mamidipalli, S. N., Parimi, R., Viriyala, R. K., Patchula, R. P., & Mood, L. R. (2007). Hypoglycemic and Anti-hyperglycemic Effect of Alcoholic Extract of Benincasa hispida in Normal and in Alloxan Induced Diabetic Rats. Pharmacognosy Magazine, 3(10), 101–102.