Effect of Celastrus paniculatus Willd. seed on adjuvant induced arthritis in Rats

ABSTRACT

In this study, the anti-arthritic effect of oral administration of petroleum ether, alcoholic extracts of Celastrus paniculatus Willd seed on Freund’s adjuvant arthritis has been studied in Wistar albino rats. The body weight loss that was found during the arthritic condition was corrected on treatment with petroleum ether, alcoholic extracts of Celastrus paniculatus Willd seed. The swelling of the paw during the secondary lesions was also markedly reduced. Hematological parameters like haemoglobin content, total WBC count, ESR and RBC were also estimated. The results indicated that the seed of Celastrus paniculatus is endowed with anti-arthritic activity.

KEYWORDS

• Celastrus paniculatus
• Anti-arthritic
• Freund’s complete adjuvant
• ESR

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