Gastroprotective effect of Lippia nodiflora L. extracts in ethanol-induced gastric lesions
H Khalil1, H Ismail2, A Taye2★, M Kamel1★ Corresponding author
- 1Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.
- 2Department of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt.
CORRESPONDENCE
A Taye
Taye A,Department of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt.
Volume 3, Issue 12 · pp. 258–259 · PUBLISHED 2007 · DOI:
ABSTRACT
Lippia nodiflora L., is a herbaceous, perennial and prostrate plant; containing a group of flavonoids. Accumulating evidence indicates potential therapeutic benefits of flavonoids as anti-oxidative in pathological conditions associated with oxidative stress. Here, we examined the gastroprotective effect of different fractions (n-Hexane, acetylacetate, aqueous and total extract) of Lippia nodiflora in ethyl alcohol-induced ulcer in rats. Our results showed that all these fractions significantly reduced gastric contents of Thiobarbituric acid reactive substances (TBARS), which represent a biochemical marker of oxidative stress associated with lipid peroxidation. This was mirrored by a marked decrease in ulcer index observed for different fractions. These data suggest a potential anti-ulcerative activity for Lippia nodiflora extracts and this might be due to, at least partly, their antioxidant property.
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Khalil, H., Ismail, H., Taye, A., & Kamel, M. (2007). Gastroprotective effect of Lippia nodiflora L. extracts in ethanol-induced gastric lesions. Pharmacognosy Magazine, 3(12), 258–259.