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Article

Effects of an extract of Cissampelos pareira on the hemorrhagic and proteolytic activities from Bothrops asper venom

B. Badilla1★, F. Chaves2★, S. Jiménez1, G. Rodríguez1, L.J. Poveda3★★ Corresponding author

  1. 1INIFAR, Facultad de Farmacia, Universidad de Costa Rica, San José, Costa Rica.
  2. 2Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.
  3. 3Facultad de Ciencias Ambientales, Universidad Nacional de Costa Rica. Heredia, Costa Rica.

CORRESPONDENCE

B. Badilla

Badilla B.,INIFAR, Facultad de Farmacia, Universidad de Costa Rica, San José, Costa Rica.

bbadilla@cariari.ucr.ac.cr

Volume 4, Issue 13 · pp. 27–28 · PUBLISHED 2008 · DOI:

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ABSTRACT

The capacity of an aqueous extract from leaves of Cissampelos pareira to neutralize the hemorrhagic and proteolytic activities of the venom of Bothrops asper was evaluated. To establish the anti-hemorrhagic activity, the skin of mice was injected with a mixture of extract and venom, and it was found that extract produced a total inhibition of this activity. On the other hand, experiments regarding the anti-proteolytic activity were conducted observing the effect on casein in a test tube or on biotinylated casein in a microplate. None of the two procedures was able to show any inhibitory activity.

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    Badilla, B., Chaves, F., Jiménez, S., Rodríguez, G., & Poveda, L. (2008). Effects of an extract of Cissampelos pareira on the hemorrhagic and proteolytic activities from Bothrops asper venom. Pharmacognosy Magazine, 4(13), 27–28.