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Article

Antinociceptive Effects of Newbouldia laevis (P. Beauv.) Stem Bark Extract in a Rat Model

George K. Ainooson1, Eric Woode1★, David D. Obiri1, George A. Koffour1★ Corresponding author

  1. 1Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.

CORRESPONDENCE

Eric Woode

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.

ewoode.pharm@knust.edu.gh

Received: 22-07-2008; Revised: 11-06-2008; Accepted: 11-06-2008.

Volume 5, Issue 17 · pp. 49–54 · PUBLISHED 2009 · DOI:

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ABSTRACT

Various parts of Newbouldia laevis (fam. Bignoniaceae) are used for pain and several inflammatory conditions in Ghana. This study presents the effect of a hydro-alcoholic extract of N. leavis stem bark in formalin-induced pain, a model of neuropathic pain, in rats. Morphine (1-10 mg kg-1 i.p) and stem bark extract of N. laevis (10-300 mg kg-1 p.o.), dose-dependently decreased both phases of the formalin-induced nociceptive behaviour. Nocifensive response for morphine was four fold higher in the first phase (ED50;1.79 ± 0.63 mg kg-1) compared to the second (ED50 ;7.59± 2.26); however the response for the extract was similar in both phases (ED50; first phase 28.28±7.02; ED50; second phase 25.07 ± 5.83). Diclofenac (10-100 mg kg-1) was effective only in the second phase (ED50 33.24± 5.20). The potency of the drugs was in the order; morphine > extract > diclofenac for the first phase and morphine > extract ≈ diclofenac for the second phase. The results from this study show that N. laevis extract has central and peripheral analgesic properties and thus adds credence to its traditional uses.

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    Ainooson, G. K., Woode, E., Obiri, D. D., & Koffour, G. A. (2009). Antinociceptive Effects of Newbouldia laevis (P. Beauv.) Stem Bark Extract in a Rat Model. Pharmacognosy Magazine, 5(17), 49–54.