Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark
Faiyaz Ahmed1★, Asna Urooj1★ Corresponding author
- 1Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangotri, Mysore - 570 006, India.
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Faiyaz Ahmed
Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangotri, Mysore - 570 006, India.
Received: 17-01-2010; Revised: 19-01-2010.
Volume 6, Issue 22 · pp. 142–144 · PUBLISHED 5 May 2010 · DOI: 10.4103/0973-1296.62897
ABSTRACT
The present study evaluated the anticholinesterase activity of cold and hot aqueous extracts of Ficus racemosa stem bark against rat brain acetylcholinesterase in vitro. Both the cold aqueous extract (FRC) and the hot aqueous extract (FRH) exhibited a dose dependent inhibition of rat brain acetylcholinesterase. FRH showed significantly higher (P ≤ 0.001) cholinesterase inhibitory activity compared to FRC; however, both the extracts did not show 50% inhibition of AChE at the doses tested (200-1000 µg ml-1). The IC50 values of 1813 and 1331 µg ml-1 were deduced for FRC and FRH, respectively (calculated by extrapolation using Boltzmann’s dose response analysis).
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Ahmed, F., & Urooj, A. (2010). Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark. Pharmacognosy Magazine, 6(22), 142–144. https://doi.org/10.4103/0973-1296.62897