Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress
Hasan Kılıçgün1★, Gülden Gökşen1★ Corresponding author
- 1Department of Nutrition and Dietetic, Erzincan University, School of Health, 24100, Erzincan, Turkey.
CORRESPONDENCE
Hasan Kılıçgün
Department of Nutrition and Dietetic, Erzincan University, School of Health, 24100, Erzincan, Turkey.
Received: 08-06-2011; Revised: 11-09-2012; Accepted: 11-09-2012.
Volume 8, Issue 32 · pp. 325–326 · PUBLISHED 22 November 2012 · DOI: 10.4103/0973-1296.103666
ABSTRACT
Background: The beneficial effects of antioxidants in plants are mainly extrapolated from in vitro studies or short-term dietary supplementation studies. Due to cost and duration, relatively little is known about whether dietary antioxidants are beneficial in whole animals’ life span or not. Materials and Methods: To address this question, under heat stress (35°C), Hypericum perforatum was extracted with petroleum ether and the nematodes Caenorhabditis elegans exposed to three different extract concentrations (1mg/mL, 0.1mg/mL, 0.01mg/mL) of H. perforatum. Results: We report that Hypericum perforatum extracts did not increase life span and slow aging related increase in C. elegans. Moreover, one fraction (1mg/mL) increased declines of C. elegans life span and thermotolerance. Conclusion: Given this mounting evidence for life span role of H. perforatum in the presence of heat stress in vivo, the question whether H. perforatum acts as a prooxidant or an antioxidant in vivo under heat stress arises.
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Kılıçgün, H., & Gökşen, G. (2012). Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress. Pharmacognosy Magazine, 8(32), 325–326. https://doi.org/10.4103/0973-1296.103666