Volume 12, Issue 47S

30 September 2016 · pp. 389–474 · 17 articles

Volume: 12
Issue: 47S
Published: 30 September 2016
Pages: 389–474
Articles: 17
Sections: 2
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

ORIGINAL ARTICLE Original Article

In this issue

ORIGINAL ARTICLE

Article
Human Cytochrome P450 Enzyme Modulation by Gymnema sylvestre : A Predictive Safety Evaluation by LC-MS/MS
Bera Rammohan, Karmakar Samit, Das Chinmoy, Saha Arup, Kundu Amit, Sarkar Ratul, Karmakar Sanmoy, Adhikari Dipan, Sen Tuhinadri
pp. 389–394 · DOI: 10.4103/0973-1296.191441 · Published 30 September 2016
Background: Traditionally GS is used to treat diabetes mellitus. Drug-herb interaction of GS via cytochrome P450 enzyme system by substrate cocktail method using HLM has not been reported. Objective: To evaluate the in-v…
Article
Evaluation of the Genotoxicity and Cytotoxicity of Semipurified Fractions from the Mediterranean Brown Algae, Dictyopteris membranacea
Najoua Akremi, Davie Cappoen, Roel Anthonissen, Abderrahman Bouraoui, Luc Verschaeve
pp. 395–9 · DOI: 10.4103/0973-1296.188318 · Published 30 September 2016
Dictyopteris membranacea, a species of Mediterranean brown algae,is believed to have potential pharmacological and nutritional applications. However, such potentials only make sense when devoid of any adverse health cons…
Article
In vitro Accumulation of Polyphenols in Tea Callus Derived from Anther
Naga Pavan Kumar Chevala, Naga Thirumalesh Chevala, Kirubakaran Dhanakodi, Rama Rao Nadendla, Chandrashekara Krishnappa Nagarathna
pp. 400–6 · DOI: 10.4103/0973-1296.191442 · Published 30 September 2016
Background: Tea is an economic important crop with high medicinal value due to rich polyphenols content. In the present research we studied the accumulation of polyphenols of in vitro regenerated callus from anthers. Obj…
Article
Genetic and Chemical Profiling of Gymnema sylvestre Accessions from Central India: Its Implication for Quality Control and Therapeutic Potential of Plant
Ashutosh Kumar Verma, Sunita Singh Dhawan, Seema Singh, Kumar Avinash Bharati, Jyotsana Jyotsana
pp. 407–13 · DOI: 10.4103/0973-1296.191443 · Published 30 September 2016
Background: Gymnema sylvestre, a vulnerable plant species, is mentioned in Indian Pharmacopeia as an antidiabetic drug Objective: Study of genetic and chemical diversity and its implications in accessions of G. sylvestre…
Article
Potential Therapeutic Agents for the Treatment of Fatty Degeneration of Liver and Atheromatous Plaques: An Experimental Study in Rats
Sibghatullah Muhammad Ali Sangi
pp. 414–23 · DOI: 10.4103/0973-1296.191444 · Published 30 September 2016
Background: Since long high fat diet (HFD) is being blamed for causing fatty degeneration of liver and formation of atheromatous plaques. At present, no proper pharmacotherapy is available for both the conditions. In thi…
Article
Influence of Extracting Solvent on Pharmacological Activity and Cytotoxicity of Polygonum minus, a Commonly Consumed Herb in Southeast Asia
Parayil Varghese Christapher, Subramani Parasuraman, Palanimuthu Vasanth Raj, Sultan Ayesh Mohammed Saghir, Mohd. Zaini Asmawi, Murugaiyah Vikneswaran
pp. 424–30 · DOI: 10.4103/0973-1296.191451 · Published 30 September 2016
Objective: To investigate the antihyperlipidemic, antioxidant, and cytotoxic effect of aqueous and methanol extract of leaves of Polygonum minus. Materials and Methods: Acute antihyperlipidemic effect was studied on chem…
Article
Phytochemicals and Cytotoxicity of Launaea procumbens on Human Cancer Cell Lines
Preeti Rawat, Lokesh M. Saroj, Anil Kumar, Tryambak D. Singh, SK. Tewari, Mahesh Pal
pp. 431–5 · DOI: 10.4103/0973-1296.191452 · Published 30 September 2016
Background: The plant Launaea procumbens belongs to the family Asteraceae and traditionally used in the treatment rheumatism, kidney, liver dysfunctions and eye diseases. In the present study Phytochemical analysis and f…
Article
Sambar, an Indian Dish Prevents the Development of Dimethyl Hydrazine-Induced Colon Cancer: A Preclinical Study
Vutturu Ganga Prasad, Neetinkumar Reddy, Albi Francis, Pawan G. Nayak, Anoop Kishore, Krishnadas Nandakumar, Mallikarjuna C. Rao, Rekha Shenoy
pp. 441–5 · DOI: 10.4103/0973-1296.191454 · Published 30 September 2016
Background: Colon cancer (CC) is the third commonly diagnosed cancer and the second leading cause of mortality in the US when compared to India where prevalence is less. Possible reason could be the vegetarian diet compr…
Article
Antihepatotoxic Effect and Metabolite Profiling of Panicum turgidum Extract via UPLC-qTOF-MS
Mohamed A. Farag, Ahlam M. Fishawy, Sayed A. El-Toumy, Khadiga F. Amer, Ahmed M. Mansour, Hala E. Taha
pp. 446–53 · DOI: 10.4103/0973-1296.191455 · Published 30 September 2016
Background: Panicum turgidum, desert grass, has not reported any detailed phytochemical or biological study as yet Objective: To establish P. turgidum secondary metabolite profile and to assess its antihepatotoxic effect…
Article
Induction, Subculture Cycle, and Regeneration of Callus in Safed Musli (Chlorophytum borivilianum) using Different Types of Phytohormones
Jaafar Juju Nakasha, Uma Rani Sinniah, Nurashikin Kemat, Kumara Swamy Mallappa
pp. 460–4 · DOI: 10.4103/0973-1296.191457 · Published 30 September 2016
Background: Chlorophytum borivilianum is an industrially valued medicinal crop. Propagation through seeds is not feasible because of low germination percentage and long dormancy period. Therefore, callus culture and plan…
Article
Postprandial Antihyperglycemic And Antioxidant Activities of Acalypha indica Linn Stem Extract: An In-vivo Study
Charles Lekhya Priya, K V Rao
pp. 475–81 · DOI: 10.4103/0973-1296.191461 · Published 30 September 2016
Background: α-glucosidase inhibitors controls postprandial hyperglycemia (PPHG) by lowering sharp rise in blood glucose levels after ingestion of carbohydrate rich meal in type 2 diabetic (T2D) individuals. Acalypha indi…
Article
Elucidation of Molecular Mechanism(s) of Cognition Enhancing Activity of Bacomind®: A Standardized Extract of Bacopa Monnieri
Shekhar Dethe, Deepak M, Amit Agarwal
pp. 482–7 · DOI: 10.4103/0973-1296.191464 · Published 30 September 2016
Background: Bacopa monnieri (L.) Wettst., commonly known as Brahmi, is renowned in Indian traditional system for its potent memory enhancing activity, which has been validated by various scientific studies. Objective: Th…
Article
Free Radical Scavenging, α-Glucosidase Inhibitory and Anti-Inflammatory Constituents from Indian Sedges, Cyperus scariosus R.Br and Cyperus rotundus L.
Lavanya Kakarla, Suresh Babu Katragadda, Ashok K Tiwari, K Srigiridhar Kotamraju, K Madhusudana, Anand Kumar D, Mahendran Botlagunta
pp. 488–96 · DOI: 10.4103/0973-1296.191467 · Published 30 September 2016
Background: Cyperus scariosus R. Br and Cyperus rotundus L are widely used in ayurvedic preparation for the treatment of diabetes and other diseases. The early literature ,so far, does not indicate the presence of any bi…

Original Article

Article
Inhibitory and Cytotoxic Activities of Chrysin on Human Breast Adenocarcinoma Cells by Induction of Apoptosis
Saeed Samarghandian, Mohsen Azimi-Nezhad, Abasalt Borji, Malihe Hasanzadeh, Farahzad Jabbari, Tahereh Farkhondeh, Mohammad Samini
pp. 436–440 · DOI: 10.4103/0973-1296.191453 · Published 30 September 2016
Objectives: Chrysin, an active natural bioflavonoid found in honey and many plant extracts, was first known for its antioxidant and anti‑inflammatory effects. The fact that antioxidants have several inhibitory effects ag…
Article
Catha edulis (khat) Induces Apoptosis in Madin‑Darby Bovine Kidney Cell Line
Hussein M. Ageely, Ahmed E. Agag, Syam Mohan, Atef Shehata
pp. 454–459 · DOI: 10.4103/0973-1296.191456 · Published 30 September 2016
Background: Khat (Catha edulis) is a controversial plant having a euphoretic effect, at the same time part of culture in many countries such as Africa and Arabian Peninsula. The presence of amphetamine-like substance, ca…
Article
Elicitation of Phenolics from the Micropropagated Endangered Medicinal Plant Calligonum polygonoides L. (Polygonoaceae)
Asmaa I. Owis, Nada S. Abdelwahab, Adel A. Abul‑Soad
pp. 465–470 · DOI: 10.4103/0973-1296.191458 · Published 30 September 2016
Background: Calligonum polygonoides L. subsp. comosum (L’Hér.) Sosk. is a plant species belonging to family Polygonaceae. Susceptibility to threaten, presence of various chemical constituents, and many medicinal effects …
Article
Assessment of In vitro Antibacterial Activity and Cytotoxicity Effect of Nigella sativa Oil
Ayse Ruveyda Ugur, Hatice Turk Dagi, Bahadir Ozturk, Gulsum Tekin, Duygu Findik
pp. 471–474 · DOI: 10.4103/0973-1296.191459 · Published 30 September 2016
Background: Methicillin resistance is a serious health concern since it has spread among Staphylococcus aureus and coagulase‑negative Staphylococci (CoNS) that are frequent community and nosocomial pathogens worldwide. M…