Volume 22, Issue 1

2026 · pp. 7–407 · 36 articles

Volume: 22
Issue: 1
Published: 2026
Pages: 7–407
Articles: 36
Sections: 2
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

Review Article Original Research Article

In this issue

Review Article

Review
Current Review on Ethnopharmacological Approach on Medicinal Value of Cordia macleodii as a Traditional Herb of Importance
Khemkaran Ahirwar, Junaid Khan, Anand Kumar, Mukesh Nag
pp. 7–16 · DOI: 10.1177/09731296251330393 · Published 2026
Background: The medicinal properties of plants and plant derivatives have led to their long-term use in medicine. Objectives: The present review article was drafted to discuss the traditional importance of Cordia macleod…
Review
Therapeutic Potential of Flavonoids in Osteosarcoma: Molecular Mechanisms and Clinical Implications
Zhenhai Cai, Jieen Pan, Xiaojun He, Wenmin Wang, Zhengwei Zhou
pp. 17–29 · DOI: 10.1177/09731296241305887 · Published 2026
Osteosarcoma (OS) is a predominant malignancy among children and adolescents, ranked third in frequency after lymphoma and leukemia. It presents a significant risk of metastasis, particularly to the lungs and distal bone…

Original Research Article

Article
Fisetin Attenuates Experimental Periodontal Disease in Rats via Regulating BMP-2/TIMP-1 and OPG/RANKL Signaling Pathways
Lu Li, Xuxi Chen, Yufei Xue, Weiyi Chen
pp. 30–42 · DOI: 10.1177/09731296251324704 · Published 2026
Background: Periodontitis is a persistent inflammatory condition that mainly affects the supportive tissues of the teeth, comprising the gingiva, periodontal ligament, and alveolar bone. Objectives: The present study foc…
Article
Curcumin Regulates Lipid Mobilization Factors Through S100A9 in Patients With Anorexia– Cachexia Syndrome in Head and Neck Cancer
Shujing Qi, Gaixia Fu, Zhaozhen Chu
pp. 43–52 · DOI: 10.1177/09731296251330001 · Published 2026
Background: Anorexia–cachexia syndrome in head and neck cancer (ACSHNC) seriously affects the patient’s quality of life and prognosis. Curcumin inhibits head and neck cancer and anorexic cachexia syndrome. S100A9 is rela…
Article
Deciphering the Intricacies of Breast Cancer Signaling Network and the Potential of Soy-derived Isoflavones on Cancer Therapeutics
Amir Mahgoub Awadelkareem, Abd Elmoneim O. Elkhalifa, Mohd Adnan, Mohammed Kuddus, Mohammed Idreesh Khan, Manojkumar Sachidanandan, Fauzia Ashfaq, Mirza Sarwar Baig, Syed Amir Ashraf
pp. 53–66 · DOI: 10.1177/09731296251322233 · Published 2026
Background: Breast cancer remains a significant global health challenge despite the emergence of various drug molecules. However, the adverse side effects of several drugs and chemotherapy necessitate the exploration of …
Article
Mechanism of Alginate-Collagen Hydrogel in the Repair of Rat Cartilage Injury
Yezhou Li, Chengjian Tang
pp. 67–79 · DOI: 10.1177/09731296251323311 · Published 2026
Background and Objectives: Alginate and gelatin have biocompatibility and biodegradability for drug formulations or carriers, but the roles and mechanisms in cartilage injury (CI) repair remain unclear. This research inv…
Article
Therapeutic Effects of Dendrobium Extract on Pathologic Lens Alterations in Diabetic Cataract Patients
Baoping Duan, Hongyan Ge, Meng Sun, Sheng Su, Shiqiang Zhao, Ping Liu
pp. 80–89 · DOI: 10.1177/09731296251325353 · Published 2026
Background: Diabetic cataract, an ocular complication arising from diabetes, can lead to damage to ocular tissues, particularly affecting the lens and causing symptoms such as blurred vision. Objectives: This work aimed …
Article
Allicin Combined with Cisplatin Inhibits the Growth and Metastasis of Lewis Cells in Lung Cancer Mice
Bin Zhang, Xinghui Ren, Juan Wang, Wei Zhang
pp. 90–98 · DOI: 10.1177/09731296251325329 · Published 2026
Background: Allicin has anti-tumor activity and an inhibitory effect on lung cancer. Objectives: In this experiment, lung cancer mice were used as the research subjects to explore the mechanism of allicin with cisplatin …
Article
Immunomodulatory and Anti-cancer Potency of Lysergol on Benzo[a]pyrene-induced Lung Carcinogenesis and Attenuation of Tumor Progression in Mice Model
Yaming Li, Jiayin Liu, Shuang Pan
pp. 99–112 · DOI: 10.1177/09731296251324741 · Published 2026
Background: Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon exposure, is a major public health issue globally, particularly as a result of its connection to lung cancer. Individuals exposed to higher levels of …
Article
Leonurine Attenuates Neuroinflammation and Oxidative Stress in a Pentylenetetrazoleinduced Epilepsy in Rats
Huan Hui, Fan Li
pp. 113–124 · DOI: 10.1177/09731296251322829 · Published 2026
Background: Epilepsy is a complex neurological condition characterized by recurrent seizures due to abnormal neuronal activity. Objectives: The major aim of this study is to examine the therapeutic activities of leonurin…
Article
A Comparative Study Between Cheilocostus speciosus (Sea Qust) and Saussurea lappa (Indian Qust): Decoding the Spectral, Anti-bacterial, and Anti-cancer Analyses
Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Syam Mohan, Mukul Sharma, Md Shamsher Alam, Mohamed Eltaib Elmobark, Sivakumar S Moni, Mohammed Albeishy, Ohood Sufyani, Afraim Koty, Adel S. Al-Zubairi
pp. 125–135 · DOI: 10.1177/09731296251324742 · Published 2026
Background: This study conducted a comprehensive comparative analysis of Cheilocostus speciosus (sea qust) and Saussurea lappa (Indian qust) using various bioanalytical techniques. Objectives: To identify the undiscovere…
Article
Integrate Molecular Docking and Animal Model Validation into the Research of the Effect and Potential Mechanism of Eupatilin Against Myocardial Ischemia/Reperfusion Injury
Yulong Li, Xiang Li
pp. 136–146 · DOI: 10.1177/09731296251323316 · Published 2026
Background: Myocardial ischemia/reperfusion (I/R) injury refers to myocardial tissue damage caused by blood reperfusion after acute heart ischemia caused by coronary artery thrombosis and others. This process is closely …
Article
Albiflorin Enhances Diabetic Wound Healing Process by Enhancing Re-epithelialization and Ameliorating Inflammation and Oxidative Stress in Diabetic Rats
Jie Yang, Xinrong Zhang, Jiawei Zhang, Lu Yan
pp. 147–157 · DOI: 10.1177/09731296251342290 · Published 2026
Background: Diabetes mellitus, a persistent metabolic disorder defined by elevated blood glucose, poses a global public health challenge. One of the most debilitating complications of this disease is the progression of c…
Article
An Investigation of the Protective Effects of Trifolirhizin against MPTP-induced Parkinson’s Disease in Mice
Xiaoli Yuan
pp. 158–166 · DOI: 10.1177/09731296251362609 · Published 2026
Background: Parkinson’s disease (PD) is a prevalent age-associated neurodegenerative disorder, primarily characterized by dopaminergic neuronal loss, oxidative stress, and microglia-mediated neuroinflammation. Current th…
Article
Licoricidin Ameliorates Renal Function via Controlling Stress and Inflammation in Experimental Diabetic Nephropathy Animal Model
Yang Li, Yan Zhao, Rou Shi, Yan Li, Yun-Yun Chen, Zhu Zhou, Hui-Fang Li
pp. 167–177 · DOI: 10.1177/09731296251361610 · Published 2026
Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and its currently the leading cause of end-stage renal disease worldwide. Reducing its incidence and delaying its progression are u…
Article
Anti-osteoarthritic Effect of High Bioavailable Curcumin Formulation by Balancing Cartilage Synthesis and Cartilage Degradation in MIA-induced Osteoarthritis Rats
Nehru Sai Suresh Chalichem, Min-Jung Kim, Tae-Jong Kim, Seung-Un Kim, Prasanna Raja, Mohammed S. Khan
pp. 178–193 · DOI: 10.1177/09731296251326792 · Published 2026
Background: Osteoarthritis affects millions of people worldwide. Currently, available pharmacological treatment is limited to topical and oral non-steroidal anti-inflammatory drugs (NSAIDs). Several studies have reported…
Article
Biological Activity and Cell Cycle Effects of Natural Extract Kaempferol on Androgendependent Prostate Cancer Cells
Meikang Peng, Tao Chen, Hongliang Peng
pp. 194–202 · DOI: 10.1177/09731296251325350 · Published 2026
Background: There is an abnormal enhancement of androgen receptor activity in prostate cancer cells, leading to increased sensitivity to androgens and the promotion of cancer cell proliferation. Objectives: This study ai…
Article
Mechanistic of Mulberry Apricot Coughing Granules in Regulating Dysregulated Fluid Metabolism and Inhibiting Ferroptosis in Cough Variant Asthma
Jianjiang Luo, Lixia Wang, Yongwei Zhao, Huifang Liu, Dan Xu, Fengsen Li
pp. 203–216 · DOI: 10.1177/09731296251325347 · Published 2026
Background: Cough variant asthma (CVA) is a distinct type of asthma manifested as dysregulation of fluid metabolism and modulation of ferroptosis. Objectives: The aim of this study was to demonstrate the regulatory effec…
Article
Dezocine Suppresses Myocardial Cell Apoptosis in Rats with Myocardial Ischemia-Reperfusion Injury via TLR4/NF-κB Signaling Pathway
Mingyan He, Ru Liu, Yalin Li, Qi Zhang
pp. 217–222 · DOI: 10.1177/09731296251325341 · Published 2026
Background: Myocardial ischemia-reperfusion (MI/R) injury is a leading cause of myocardial damage, characterized by apoptosis and impaired cardiac function. Dezocine, a mixed opioid receptor agonist/antagonist, has shown…
Article
Ferulic Acid Alleviates Mycoplasma pneumoniaeinduced Pneumonia in Mice by Regulation of Inflammation and ERK/JNK/NF-κB Pathway
Ping Ren, Rongjuan Xi
pp. 223–234 · DOI: 10.1177/09731296251330715 · Published 2026
Background: Pneumonia is a serious respiratory illness that impacts the lungs, leading to inflammation and fluid accumulation in the alveoli, the tiny air sacs essential for gas exchange. Mycoplasma pneumonia is a severe…
Article
Mechanistic Insights into the Immunomodulatory Effects of Velvet Antler Peptides from Sika Deer
Lan-Yue Yin, Jiating Li, Xue-Yue Tai, Guo-Qi Zhang, Ming-Ran Luan, Wu-Yang Hua, Chao Liu, Bao Zhong, Feng-Lin Li
pp. 235–242 · DOI: 10.1177/09731296251329997 · Published 2026
Background: Sika deer antler is a traditional Chinese medicine, and its mechanism of action on immune regulation is still unclear. Therefore, this study aims to explore its related mechanism. Objectives: To investigate t…
Article
Comparative Neuropharmacological Evaluation of Two Herbs (Rosemary and Basil) with Culinary, Medicinal, and Cultural Significance
Sulaiman Mohammed Alnasser
pp. 243–252 · DOI: 10.1177/09731296251331672 · Published 2026
Background: Rosemary (Rosmarinus officinalis) is a perennial herb, while basil (Ocimum basilicum) is an annual herb. Both are utilized in culinary practices and have antioxidant as well as anti-inflammatory properties. H…
Article
Sophocarpine Alleviates Inflammationinduced Colonic Epithelial Barrier Dysfunction in Ulcerative Colitis
Yanmin Zhang, Tianzhi Liu, Zhigang Zuo
pp. 253–264 · DOI: 10.1177/09731296251333262 · Published 2026
Background: Sophocarpine, a quinoline alkaloid derived from Sophora alopecuroides L., is known for its anti-inflammatory effects. These effects are achieved by modulating both nuclear factor-κB (NF-κB) pathway and node-l…
Article
Mechanism of Action of Raspberry Natural Extract on Apoptosis in Human Brain Artery Aneurysm Vascular Endothelial Cells
Junti Lu, Yanhui Zhou, Zhenyu Xia, Bowen Yang, Gao Wu, Hui Gui, Shiwen Guo
pp. 265–276 · DOI: 10.1177/09731296251321210 · Published 2026
Background and Objectives: Raspberry natural extract exhibits a regulatory effect on apoptosis in human brain artery aneurysm vascular endothelial cells (VECs). This work was to gain deeper insights into the impact of ra…
Article
Mechanism of Ginkgo Diterpene Lactone Meglumine Injection Promoting Angiogenesis and Improving Cerebral Perfusion in Cerebral Infarction Rats
Tao Zhan, Ruixia Li, Jiahui Shen, Xinya Chen, Pingguo Liu
pp. 277–288 · DOI: 10.1177/09731296251313639 · Published 2026
Background: In recent years, traditional Chinese medicine has shown advantages in treating ischemic cerebrovascular diseases, including multi-component, multi-target, and low toxicity effects. Objectives: The aim of this…
Article
α-Mangostin Shows Chemopreventive Activity in Benzo[a]pyrene-induced Lung Cancer in Mice Via Regulation of Apoptosis and Tumor Biomarkers
Yuan Feng, Jinxiu Guo, Chao Wang, Zonglin Shi
pp. 289–299 · DOI: 10.1177/09731296251341499 · Published 2026
Background: Lung cancer is a serious disease affecting millions of individuals globally, defined by the unregulated proliferation of abnormal cells in the lungs. It is the primary cause of cancer-associated fatalities wo…
Article
Vicenin-2 Exerts Bidirectional Immunomodulation via p38MAPK Phosphorylation in RAW264.7 Macrophages
Xi Duan, Shuang Du, Hao Yang, Jia He, Lei Zhang, Yunzhu Mu
pp. 300–310 · DOI: 10.1177/09731296251360569 · Published 2026
Background: Inflammatory diseases, including autoimmune disorders, and chronic inflammatory conditions, are driven by dysregulated immune responses, particularly involving macrophage activation. Macrophages play a critic…
Article
The Purified Fraction of Persicaria capitata Flowers Attenuates Proliferation in A-431 Cell Lines
Vikrant Arya, Amandeep Kaur Gill, Yatendra Singh, Ashutosh Acharya, Anupam Jamwal
pp. 311–320 · DOI: 10.1177/09731296251333884 · Published 2026
Background: Squamous cell carcinoma is a skin carcinoma and can be fatal if not cured on time. Overexposure to ultraviolet (UV) light is the most common causative agent responsible for such a condition. Genetic and immun…
Article
Sinensetin Shows Neuroprotective Effects in Aluminum Chloride-induced Alzheimer’s Disease in Rats by Regulating BDNF/PPAR-γ/p38MAPK/NF-κB Pathways
Fuhua Gong, Yujia Su, Tao Wu, Tahani Awad Alahmadi, Hesham S. Almoallim
pp. 321–333 · DOI: 10.1177/09731296251379601 · Published 2026
Background: Alzheimer’s disease (AD) is a neurological disorder characterized by behavioral and memory deficits, along with cognitive impairments. The majority of AD cases are often present in individuals aged 60 and abo…
Article
Sophoricoside Inhibits Cell Growth and Induces Oxidative Stress-dependent Apoptosis in Colon Cancer HCT-116 Cells
Zheng Zhang, Qian Zheng, Dongli Zhang, Shaowen Li
pp. 334–341 · DOI: 10.1177/09731296251361618 · Published 2026
Background: Colorectal cancer constitutes a major global health issue, defined by the unregulated growth of atypical cells in the large intestine or rectum. This intricate disease, resulting from a combination of genetic…
Article
Forsythia suspensa Ethanolic Extract Alleviates Mycoplasma pneumoniae-induced Lung Inflammation via Inhibition of NF-κB Signaling
Yuhang Xue, Ji Hui, Juan Li, Xia Li, Jifeng Tian, Yanping Shi
pp. 342–353 · DOI: 10.1177/09731296251346353 · Published 2026
Background/Objectives: Mycoplasma pneumoniae is a significant contributor to respiratory tract infections, notably community-acquired pneumonia (CAP), bronchitis, and exacerbations of chronic lung diseases. Its epidemiol…
Article
Diosmetin Enhances Apoptosis in Thyroid Cancer CAL-62 Cells via Increasing Oxidative Stress and Inhibiting PI3K/AKT/mTOR Pathway
Zhibin Jiang, Dandan Liu, Jia Lv, Xiaoli Chen, Xiaoxu Zhou, Qian Sun, Hongli Yang
pp. 354–362 · DOI: 10.1177/09731296251348747 · Published 2026
Background: Thyroid cancer is a malignancy that arises from the thyroid gland. While it is considered an uncommon condition, cases of thyroid cancer have been steadily rising in recent years worldwide. Objectives: The pr…
Article
Scopoletin Induces Apoptosis in Ovarian Cancer A2780 Cells via Regulating Caspases and Bax/Bcl-2 Pathway
Fang Wang, Limin Chen, Jie Cui, Shasha Bai
pp. 363–372 · DOI: 10.1177/09731296251348751 · Published 2026
Background: Ovarian cancer is a devastating disease that affects the female reproductive system, specifically the ovaries, which are responsible for producing eggs and the female reproductive hormones. Despite improvemen…
Article
Tribulosin Alleviates Ovariectomy-induced Osteoporosis by Inhibiting the RANKL Pathway and Inflammatory Responses
Haifei Zhang, Kai Li
pp. 373–384 · DOI: 10.1177/09731296251360086 · Published 2026
Background/Objectives: Osteoporosis is a prevalent metabolic bone disorder characterized by a progressive loss of bone density and structural deterioration, significantly affecting the geriatric population, particularly …
Article
Xanthohumol Activates Pro-apoptotic Mechanisms in Renal Cancer A498 Cells by Increasing Apoptotic Proteins and Inhibiting PI3K/AKT/mTOR Pathway
Zhongkang Lai, Ziyan Wang
pp. 385–394 · DOI: 10.1177/09731296251351701 · Published 2026
Background: Kidney cancer, also called renal cancer, is a kind of malignancy that develops in the kidneys. Kidney cancer is a major health issue that has garnered increasing attention in the medical community due to its …
Article
Sesquiterpene Curzerenone Activates Apoptotic Signaling and Attenuates PI3K/AKT/mTOR Signaling in HepG2 Cells by Triggering Oxidative Stress
Yujian Tian, Zhongjie Cao, Renshuan Li
pp. 395–406 · DOI: 10.1177/09731296251348104 · Published 2026
Background/Objectives: Curzerenone is a sesquiterpene primarily isolated from Curcuma zedoaria rhizomes, identified for its diverse therapeutic efficacy. Recent studies have highlighted curzerenone’s potential anti-cance…