jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Pharmacognosy ResearchNOW IN
Article

Cytotoxic acetogenins from Annona glabra cultivated in Egypt

Ahmed Abdel-lateff1★, Bassem S. El-Menshawi2, Mohamed Y. Haggag3, Mahmoud A. Nawwar4★ Corresponding author

  1. 1aPharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
  2. 2bPharmacognosy Department, National Research Centre Dokki, 12622 Giza, Egypt.
  3. 3cPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
  4. 4dTanning and Protein Department, National Research Centre Dokki, Giza Egypt

CORRESPONDENCE

Ahmed Abdel-lateff

*Telephone & fax 002-086-2369075

aabelazim@yahoo.co.uk

Received: 10-03-2009; Accepted: 09-04-2009.

Volume 1, Issue 3 · pp. 130–135 · PUBLISHED May-Jun 2009 · DOI:

View on PR original site ↗

ABSTRACT

Bio-assay guided fraction of the methanolic extract of Annona glabra seeds (Annonaceae), cultivated in Egypt, revealed to the isolation of three bis-tetrahydrofuran acetogenins; squamocin-C (1), squamocin-D (2), and annonin I (3). Compounds 1 and 2 were obtained as stereoisomeric mixture. All isolates were assayed for their cytotoxicity twards brine shrimp and five in vitro cancer cell lines (A549, HT29, MCF 7, RPMI, and U251), and showed significant activity The structures of all compounds were determined by interpretation of their NMR and MS analyses.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Abdel-lateff, A., El-Menshawi, B. S., Haggag, M. Y., & Nawwar, M. A. (2009). Cytotoxic acetogenins from Annona glabra cultivated in Egypt. Pharmacognosy Research, 1(3), 130–135.