Evaluation of AntiCancer Activity of Methanolic Extract of Hiptage benghalensis (L.) Kurz on Cancer Cell Lines
Babu Rao Bhukya1, Narsimha Reddy Yellu1★★ Corresponding author
- 1Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, INDIA.
CORRESPONDENCE
Narsimha Reddy Yellu
Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, INDIA.
Volume 10, Issue 3 · pp. 309–313 · PUBLISHED · DOI: 10.4103/pr.pr_102_17
ABSTRACT
Aim and Background: This study aimed to study the anticancer effects of Hiptage benghalensis (L.) kurz using various human cancer cell cultures, in vitro using 3‑(4,5‑Dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide MTT assay. Materials and Methods:Human cervical carcinoma (HeLa) cells, human breast cancer (MCF‑7) cells, and human neuroblastoma (IMR‑32) cells were maintained in a 5% CO2 incubator at 37°C. Different concentrations of an extract of H. benghalensis in serum‑free culture medium were freshly prepared and used for cytotoxic activity using MTT assay activity. Results: Among the plant extract had revealed that, the greater percentage inhibition in all types of cancer cells in a dose‑dependent manner using MTT assay. The concentration of the extract causing 50% cell death values of methanolic extract of H. benghalensis were found to be 50.73, 47.90, and 53.76 μg/mL against HeLa, MCF‑7, and IMR‑32, respectively. Conclusion:H. benghalensismethanolic extract were showed increased percentage inhibition of MCF 7, HeLa, and IMR 32 cells using MTT assay.
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Bhukya, B. R., & Yellu, N. R. (). Evaluation of AntiCancer Activity of Methanolic Extract of Hiptage benghalensis (L.) Kurz on Cancer Cell Lines. Pharmacognosy Research, 10(3), 309–313. https://doi.org/10.4103/pr.pr_102_17