Physicochemical and in vitro Analysis of Herbal Drugs A. indica, C. longa, P. pinnata, P. corylifolia, W. fruticosa for Potential Effect in Psoriasis
Arun Kumar1, Saurabh Singh1★, Bimlesh Kumar1, Sheetu Wadhwa1, Dileep Singh Baghel1, Narendra Kumar Panday1, Sachin Kumar Singh1, Shivani Shivani1, Vikas Kumar Pal1★ Corresponding author
- 1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, INDIA.
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Saurabh Singh
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, INDIA.
Received: 30-07-2023; Revised: 20-08-2023; Accepted: 12-09-2023.
Volume 15, Issue 4 · pp. 831–840 · PUBLISHED · DOI: 10.5530/pres.15.4.088
ABSTRACT
Background: Curcuma longa (Zingiberaceae), Azadirachta indica (Meliaceae), Psoralea corylifolia (Fabaceae), Pongamia pinnata (Fabaceae), and Woodfordia fruticosa (Lythraceae) stand as renowned medicinal plants in India. Traditionally, different parts of these plants have been employed for healing, particularly in the context of treating psoriasis and various other ailments. This catalyzed our investigation into the potential antipsoriatic properties of these botanicals. Objectives: We set out to evaluate the preliminary phytochemical analysis and in vitro antipsoriatic capabilities of acetone, ethanol, and water extracts derived from Curcuma longa, Azadirachta indica, Psoralea corylifolia, Pongamia pinnata, andWoodfordia fruticosa. Materials and Methods:The antipsoriatic potential of these extracts was assessed through the MTT assay, using HaCaT cells. Additionally, we conducted LDH assays and utilized confocal microscopy to gain further insights. Results:Our investigations unveiled the promising antiproliferative activity of these plants on skin keratinocytes. Notably, compounds A, B, and C demonstrated a significant decrease in cell viability compared to the control group. In contrast, compounds D and E did not exhibit significant differences compared to the control. Discussion and Conclusion:These findings substantiate the traditional uses of these plants in the treatment of psoriasis and underscore their potential as valuable resources in the quest for effective antipsoriatic treatments.
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Kumar, A., Singh, S., Kumar, B., Wadhwa, S., Baghel, D. S., Panday, N. K., Singh, S. K., Shivani, S., & Pal, V. K. (). Physicochemical and in vitro Analysis of Herbal Drugs A. indica, C. longa, P. pinnata, P. corylifolia, W. fruticosa for Potential Effect in Psoriasis. Pharmacognosy Research, 15(4), 831–840. https://doi.org/10.5530/pres.15.4.088