Calotropin: Natural Phytomolecules for Cutting-edge Features
Sourav Nag1, Reshmi Paul1, Sumanta Mondal1★, Naresh Panigrahi1, Partha Roy1★ Corresponding author
- 1Department of Pharmaceutical Chemistry, School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, INDIA.
CORRESPONDENCE
Sumanta Mondal
Department of Pharmaceutical Chemistry, School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, INDIA.
Received: 08-09-2023; Revised: 18-10-2023; Accepted: 09-11-2023.
Volume 16, Issue 1 · pp. 19–25 · PUBLISHED · DOI: 10.5530/pres.16.1.3
ABSTRACT
Phytochemical is a collective term for plant chemicals with varied structure and function. The most common sources of phytochemicals are fruits, vegetables, whole grains, nuts and seeds, and other plant foods. Calotropin is a pharmacologically active compound isolated from milkweed plants likeCalotropis procera, Calotropis gigantea, and Asclepias curassavicathat belong to the Asclepiadaceae family which is used for medicinal purposes in many Asian countries. Calotropin is identified as a highly potent cardenolide that has a similar chemical structure to cardiac glycosides (such as digoxin and digitoxin). Among cardenolides, calotropin is identified as the most promising agent. Calotropin has cytotoxic and anti-tumor impacts, with cancers of the breast, colon, lung, and leukemia malignancies exhibiting the most significant effects. The effects of calotropin on cancer have been extensively studied in preclinical pharmacological studies in vitrousing cancer cell lines andin vivoin experimental animal models that have targeted antitumor mechanisms and anticancer signaling pathways. During ancient times, calotropin was utilized in various techniques. A macerated bark extract is frequently utilized for de-hearing hides and tanning. Calotropin is a particularly effective abortifacient or interceptive agent in females. Cardenolide calotropin is poisonous. This critique focused on its chemistry and therapeutic activity in various cancer cells.
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Nag, S., Paul, R., Mondal, S., Panigrahi, N., & Roy, P. (). Calotropin: Natural Phytomolecules for Cutting-edge Features. Pharmacognosy Research, 16(1), 19–25. https://doi.org/10.5530/pres.16.1.3