In silico Insights Into the Medicinal Potential of Phyllanthus amarus: Phytoconstituents and Therapeutic Applications
Ayushi Varshney1, Pawan Kumar Gupta1, Prashant Kumar1, Shashi Bhooshan Tiwari1★★ Corresponding author
- 1Department of Pharmacy, M.J.P. Rohilkhand University Campus, Bareilly, Uttar Pradesh, INDIA.
CORRESPONDENCE
Shashi Bhooshan Tiwari
Department of Pharmacy, M.J.P. Rohilkhand University Campus, Bareilly-243006, Uttar Pradesh, INDIA.
Received: 28-02-2025; Revised: 07-04-2025; Accepted: 13-06-2025.
Volume 17, Issue 3 · pp. 707–718 · PUBLISHED Jul-Sep 2025 · DOI: 10.5530/pres.20252168
ABSTRACT
Phyllanthus amarus is a globally distributed herb. Over the 3000 years, it has been used as traditional medicine. This plant is articulated in different languages differently like in Hindi- Bhuyiavla, Jangli amla, Marathi- Bhuivali, Bihari- Muikoa, Sanskrit- Bhumyaamlaki, etc. It is an herb that can grow between 30 and 75 cm tall annually. Worldwide, Phyllanthus amarus is a plant widely distributed in tropical and subtropical areas. In Indian Ayurveda, the Phyllanthus amarus is used as a traditional medicine. It treats various diseases such as cough, diuretics, menstrual problems, stomach, kidney, etc. Scientific research said that Phyllanthus amarus exhibits potency against multiple diseases including diabetes, arthritis, inflammation, convulsion, neuroactive, hepatoprotective, nephroprotective, vasoconstriction, etc. Phyllanthus amarus has several secondary metabolites such as tannin, flavonoid, saponin, alkaloids, terpenoids, lignans, sterols, and volatile oils. Aqueous and non-aqueous extraction of Phyllanthus amarus and isolation of chemical compounds such as securinine, phyllanthine, rutin, quercitrin, amariin, geraniin, hypophyllanthins, isonirtetralin, amarosterol-A, phytol, phenazine, ursolic-acid, isolintetralin, etc. These compounds are responsible for pharmacological activity such as anti-cancer, antibacterial, analgesic, antifungal, antioxidant, antiviral, contraceptive, anti-inflammatory, etc. On the other hand, molecular docking is a potent computational process for studying molecular interactions from the drug discovery perspective. It is applied to forecast the orientation in which small drug molecules will bind to their protein targets, predicting their affinity and activity.
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Varshney, A., Gupta, P. K., Kumar, P., & Tiwari, S. B. (2025). In silico Insights Into the Medicinal Potential of Phyllanthus amarus: Phytoconstituents and Therapeutic Applications. Pharmacognosy Research, 17(3), 707–718. https://doi.org/10.5530/pres.20252168