Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. Leaves

ABSTRACT

Background The objective of the present study was to evaluate the anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. (MJL) (Nyctaginaceae) leaves for scientific validation of the folklore claim of the plant. The leaves are used as traditional folk medicine in the south of Brazil to treat inflammatory and painful diseases. Cosmetic or dermo-pharmaceutical compositions containing MJL are claimed to be useful against inflammation and dry skin. Methods Aqueous extract of the leaves was prepared by cold maceration. Results The anti-inflammatory activity was evaluated using carrageenan and formalin-induced paw edema models in Wistar albino rats. The anti-inflammatory activity was found to be dose dependent in carrageenan-induced paw edema model. The aqueous extract has shown significant (P < 0.05) inhibition of paw oedema, 37.5% and 54.0% on 4th hour at the doses of 200 and 400 mg/kg, respectively. Similar pattern of paw edema inhibition was seen in formalin-induced paw edema model. The maximum percentage inhibition in paw edema was 32.9% and 43.0% on 4th day at the doses of 200 and 400 mg/kg, respectively. Conclusion The results of present study demonstrate that aqueous extract of the leaves possess significant (P < 0.05) anti-inflammatory potential.

KEYWORDS

• Anti-inflammatory activity
• aqueous extract
• Mirabilis jalapa
• paw edema

Showing references and in-text citations exactly as published.

• DOI10.4103/0974-8490.75456Copy

RELATED ARTICLES

Matched on section and article type within this issue of PR.

• Article · VOLUME 2, ISSUE 6Secondary metabolites and bioactivities of Myrtus communisMahmoud I. Nassar, El-Sayed A. Aboutabl, Rania F. Ahmed, Ezzel-Din A. El-Khrisy, Khaled M. Ibrahim, Amany A. Sleem · pp. 325–329ORIGINAL ARTICLESame type: Article
• Article · VOLUME 2, ISSUE 6Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stress-induced behavioral and biochemical alteration in male albino miceD. Jaya Prakash, S. ArulKumar, M. Sabesan · pp. 330–334ORIGINAL ARTICLESame type: Article
• Article · VOLUME 2, ISSUE 6A comparison of the cytotoxic potential of standardized aqueous and ethanolic extracts of a polyherbal mixture comprised of Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizome)Sameera R. Samarakoon, Ira Thabrew, Prasanna B. Galhena, Dilip De Silva, Kamani H. Tennekoon · pp. 335–342ORIGINAL ARTICLESame type: Article
• Article · VOLUME 2, ISSUE 6Isolation and characterization of phytoconstituents from Chlorophytum borivilianumSharada L. Deore, Somshekhar S. Khadabadi · pp. 343–349ORIGINAL ARTICLESame type: Article