Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of Solanum torvum Swartz (Solanaceae)
George A. Koffuor1★, Patrick Amoateng1, Terrick A. Andey1★ Corresponding author
- 1Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kumasi, Ghana
CORRESPONDENCE
George A. Koffuor
*Address for correspondence: George A. Koffuor, Department of Pharmacology, KNUST, Kumasi, Ghana.
Revised: 25-03-2011.
Volume 3, Issue 2 · pp. 130–134 · PUBLISHED January 2011 · DOI: 10.4103/0974-8490.81961
ABSTRACT
Aim The effect of Solanum torvum (Fam: Solanaceae) on delayed type hypersensitivity (DTH) response, hemagglutinating antibody (HA) titer, white blood cells (WBC), red blood cells (RBC) and hemoglobin concentration was investigated in Sprague-Dawley rats to establish immunomodulatory and erythropoietic activity. Materials and Methods Sheep red blood cells (SRBC)-immunized and challenged rats were treated with Solanum torvum extract, levamisole and dexamethasone. Phenylhydrazine (PHZ)-induced anemia in rats was treated with the extract. Results The aqueous Solanum torvum extract and levamisole significantly enhanced DTH response, increased HA titer and WBC count, while dexamethasone significantly decreased DTH response, did not increase HA titer, and did not enhance WBC profile. The extract and Feroglobin, the reference heamatinic, were able to reverse PHZ-induced anemia, and increase the RBCs and Hb concentration above baseline values within 24 days. Conclusion Solanum torvum extract showed a concentration- dependent immunostimulant and erythropoietic activity.
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Koffuor, G. A., Amoateng, P., & Andey, T. A. (2011). Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of Solanum torvum Swartz (Solanaceae). Pharmacognosy Research, 3(2), 130–134. https://doi.org/10.4103/0974-8490.81961