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Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs

Mina T. Ibulubo1, Gerald I. Eze1, Raymond I. Ozolua2★, Doroteo Baxter-Grillo1, Dickson O. Uwaya2★ Corresponding author

  1. 1Department of Anatomy, School of Basic Medical Sciences, University of Benin, Benin City
  2. 2Department of Pharmacology and Toxicology, School of Pharmacy, University of Benin, Benin City, Nigeria

CORRESPONDENCE

Raymond I. Ozolua

*Address for correspondence: Dr. R. I. Ozolua, Department of Pharmacology and Toxicology, University of Benin, Benin City-300001, Nigeria.

ozolua@uniben.edu

Revised: 23-01-2012.

Volume 4, Issue 4 · pp. 203–207 · PUBLISHED October-December 2012 · DOI: 10.4103/0974-8490.102262

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ABSTRACT

Background Garcinia kola is popularly used in African traditional medicine for the relief of acute bronchoconstrictive episodes. Objective In this study, we examined the anti-asthmatic and morphological effects of the ethanol extract of G. kola in animal model. Materials and Methods Guinea pigs were sensitized with ovalbumin and then given doses of 200 or 400 mg/kg/day for 21 consecutive days. Theophylline (10 mg/kg/day) was used as a standard. At the end of the exposure, the animals were exposed to 0.2% histamine aerosol in a chamber. Lymphocyte count, bronchial histology and morphometry were done. Results Compared with non-sensitized controls, 200 mg/kg/day dose of the extract significantly (P < 0.05) increased the time taken for onset of preconvulsive dyspnea while the dose of 400 mg/kg/day significantly (P < 0.01) reduced bronchial wall thickness. Lymphocytes counts were not significantly affected but the bronchi of extract-treated animals were histologically clearer of lesions visible in the sensitized. Conclusion These protective and ameliorative properties lend credence to the use of G. kola in ethnomedicine.

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    Ibulubo, M. T., Eze, G. I., Ozolua, R. I., Baxter-Grillo, D., & Uwaya, D. O. (2012). Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs. Pharmacognosy Research, 4(4), 203–207. https://doi.org/10.4103/0974-8490.102262