Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum
Mahmoud I. Nassar1★, El-Sayed A. Aboutabl2, Dina M. Eskander1, Mary H. Grace1, Ezzel-Din A. EL-Khrisy1, Amany A. Sleem3★ Corresponding author
- 1Department of Chemistry of Natural Compounds, National Research Centre, Dokki
- 2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University
- 3Department of Pharmacognosy, National Research Centre, Dokki, Cairo, Egypt
CORRESPONDENCE
Mahmoud I. Nassar
*Address for correspondence: Dr. Mahmoud I Nassar, Department of Chemistry of Natural Compounds, National Research Centre, 12622 Dokki,Cairo, Egypt.
Revised: 25-04-2012.
Volume 5, Issue 1 · pp. 17–21 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.105643
ABSTRACT
Background Nothing is reported on Amphilophium paniculatum (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of Amphilophium paniculatum, grown in Egypt, in addition to pharmacological evaluation. Materials and Methods Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of A. paniculatum leaves. Results Identification of a new flavone glycoside, acacetin 8-C-b–D- glucopyranosy l-(1®2)–a-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD50) revealed that the different extracts were safe.
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Nassar, M. I., Aboutabl, E. A., Eskander, D. M., Grace, M. H., EL-Khrisy, E. A., & Sleem, A. A. (2013). Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum. Pharmacognosy Research, 5(1), 17–21. https://doi.org/10.4103/0974-8490.105643