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Pharmacognosy ResearchNOW IN
Article

Anti-arthritic activity of root bark of Oroxylum indicum (L.) vent against adjuvant-induced arthritis

Mamatha Karnati1, Rodda H. Chandra1, Ciddi Veeresham2★, Bookya Kishan3★ Corresponding author

  1. 1Department of Pharmacognosy and Phytochemistry, Vaagdevi College of Pharmacy, Hanamkonda, Warangal
  2. 2Department of Pharmacognosy and Phytochemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal
  3. 3Department of Pathology, Kakatiya Medical College, Warangal, Andhra Pradesh, India

CORRESPONDENCE

Ciddi Veeresham

*Address for correspondence: Prof. Ciddi Veeresham, Department of Pharmacognosy and Phytochemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India.

ciddiveeresham@yahoo.co.in

Revised: 14-09-2012.

Volume 5, Issue 2 · pp. 121–128 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.110543

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ABSTRACT

Background Oroxylum indicum (Bignoniaceae) also known as Sonapatha is an indigenous medicinal plant widely used in Ayurvedic medicine for over thousands of years. It is an active ingredient of well-known Ayurvedic formulations such as Chyawanprash and Dasamula. Root bark of this plant has tonic and astringent properties and it is also used in rheumatism. Objective The present investigation was carried out to evaluate the anti-arthritic activity of different extracts of root bark of Oroxylum indicum against adjuvant - induced arthritis in rats. Materials and Methods Male Wistar rats were used in this study. Arthritis was induced by injecting 0.1 ml Freund’s complete adjuvant intra-dermally into the left hind paw of the rats. The paw volume, hematological, biochemical, radiographic and histopathological aspects were evaluated. Results The relative percentage inhibition potential of paw volume in rats treated with various extracts of Oroxylum indicum was found to be ethyl acetate extract (67.69%) >chloroform extract (64.61%) >n-butanol extract (58.46%) respectively. The hematological parameters like RBC count, hemoglobin content showed significant increase while there was a significant decrease in total WBC count and ESR in all the groups of animals pretreated with root bark extracts. The biochemical parameters such as catalase, glutathione contents showed a significant increase while the lipid peroxide and Cathepsin-D content decreased significantly only in case of ethyl acetate pretreated rats when compared to others. Conclusion The present study suggests that the chloroform, ethyl acetate and n-butanol extracts of root bark of Oroxylum indicum exhibit anti-arthritic activity. The order of activity of extracts was found to be ethyl acetate >chloroform >n-butanol respectively.

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    Karnati, M., Chandra, R. H., Veeresham, C., & Kishan, B. (2013). Anti-arthritic activity of root bark of Oroxylum indicum (L.) vent against adjuvant-induced arthritis. Pharmacognosy Research, 5(2), 121–128. https://doi.org/10.4103/0974-8490.110543