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Antioxidant and toxicological evaluation of Cassia sophera in streptozotocin-induced diabetic Wistar rats

Rambir Singh1, Priyanka Bhardwaj1, Poonam Sharma2★★ Corresponding author

  1. 1Departments of Biomedical Sciences, Bundelkhand University
  2. 2Zoology, Institute of Basic Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

CORRESPONDENCE

Poonam Sharma

*Address for correspondence: Dr. Poonam Sharma, Department of Zoology, Institute of Basic Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India.

pnm245@yahoo.com

Revised: 01-03-2013.

Volume 5, Issue 4 · pp. 225–232 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.118767

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ABSTRACT

Background Multiple-organ failure is the main cause of death in diabetes mellitus (DM). Hyperglycemia-induced oxidative stress is responsible for major diabetic complications, including multiple-organ failure. Medicinal plants possessing antioxidant activity may reduce oxidative stress and improve the functions of various organs affected by hyperglycemia. Objectives This study was designed to evaluate the antioxidant effect of Aqueous Extract of Cassia sophera (AECS) in streptozotocin (STZ)-induced diabetic Wistar rats. Materials and Methods AECS (200 mg/kg body weight (bw)) and the standard antidiabetic drug glibenclamide (10 mg/kgbw) were administered orally by gavaging for 28 days. Results Oral administration of AECS inhibited STZ-induced increase in lipid peroxidation (LPO), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), bilirubin, creatinine and urea in liver of diabetic rats. Significant increase in activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and a reduced level of glutathione (GSH), were observed in the liver, kidney, pancreas and testis on AECS treatment. Conclusion The results demonstrate that AECS is not only useful in controlling blood glucose, but also has antioxidant potential to protect the liver, kidney, pancreas and testis against damage caused by hyperglycemia-induced oxidative stress.

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    Singh, R., Bhardwaj, P., & Sharma, P. (2013). Antioxidant and toxicological evaluation of Cassia sophera in streptozotocin-induced diabetic Wistar rats. Pharmacognosy Research, 5(4), 225–232. https://doi.org/10.4103/0974-8490.118767