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Pharmacognosy ResearchNOW IN
Article

Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens

Nasrin Payghami1, Shahla Jamili2, Abdolhossein Rustaiyan3, Soodabeh Saeidnia4, Marjan Nikan4, Ahmad Reza Gohari4★★ Corresponding author

  1. 1Departments of Marine Science and Technology
  2. 2Marine Biology
  3. 3Chemistry, Science and Research Branch, Islamic Azad University
  4. 4Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran

CORRESPONDENCE

Ahmad Reza Gohari

*Address for correspondence: Dr. Ahmad Reza Gohari, Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran.

goharii_a@tums.ac.ir

Revised: 10-12-2014.

Volume 7, Issue 4 · pp. 314–321 · PUBLISHED October-December 2015 · DOI: 10.4103/0974-8490.167893

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ABSTRACT

Background Sargassum species (phaeophyceae) are economically important brown algae in southern parts of Iran. Sargassum is mainly harvested as a row material in alginate production industries and is a source of plant foods or plant bio-stimulants even a component of animal foods. Objective In this study, Sargassum glaucescens, collected from the seashore of Chabahar, was employed for phytochemical and biological evaluations. Materials and Methods For that purpose, the dried algae was extracted by methanol and subjected to different chromatographic separation methods. Results Six sterols, fucosterol (1), 24(S)-hydroxy-24-vinylcholesterol (2), 24(R)-hydroxy-24-vinylcholesterol (3), stigmasterol (4), b-sitosterol (5) and cholesterol (6) were identified by spectroscopic methods including 1H-NMR, 13C-NMR and mass spectroscopy. In vitro alpha-amylase inhibitory test was performed on the methanolic extract and the results revealed a potent inhibition (IC50 = 8.9 ± 2.4 mg/mL) of the enzyme compared to acarbose as a positive control. Conclusion Various biological activities and distribution of sterols in Sargassum genus have been critically reviewed here. The results concluded that these algae are a good candidate for further anti-diabetic investigations in animals and human.

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    Payghami, N., Jamili, S., Rustaiyan, A., Saeidnia, S., Nikan, M., & Gohari, A. R. (2015). Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens. Pharmacognosy Research, 7(4), 314–321. https://doi.org/10.4103/0974-8490.167893