Antidermatophytic Activity of Mikania micrantha Kunth: An Invasive Weed
Madhavankutty Jyothilakshmi1, Mathew Jyothis2, Mukalel Sankunni Latha1★★ Corresponding author
- 1Biochemistry and Pharmacognosy Research Lab, School of Biosciences, Mahatma Gandhi University
- 2Microbiology Research Lab, School of Biosciences, Mahatma Gandhi University, Kottayam, India
CORRESPONDENCE
Mukalel Sankunni Latha
*Address for correspondence: Prof. Mukalel Sankunni Latha, School of Biosciences, Mahatma Gandhi University, P.D. Hills P.O, Kottayam - 686 560, Kerala, India.
Revised: 08-01-2015.
Volume 7, Issue 5S · pp. S20–S25 · PUBLISHED 2015 · DOI: 10.4103/0974-8490.157994
ABSTRACT
Context The incidence of dermatophytosis has risen dramatically in recent years. Limited availability of side-effect free drugs has led to a search for new antidermatophytic agents. Objective The objective was to investigate antidermatophytic activity and in vitro anti-inflammatory activity (protease inhibition assay) of whole plant (aerial parts only) of Mikania micrantha. Materials and Methods The dried and powdered aerial parts of M. micrantha were extracted separately with petroleum ether, ethyl acetate and methanol. Antidermatophytic activity was determined by agar tube dilution method against Epidermophyton floccosum var. nigricans, Microsporum canis, Microsporum gypseum and Trichophyton rubrum. The activities of various parts of the plant – flowers, leaves and stem were separately analyzed using their ethyl acetate extract. Fungicidal efficacy and trypsin inhibiting activity of the whole plant, flowers and leaves were also analyzed using the ethyl acetate extracts. Statistical Analysis Used For trypsin inhibition assay results are expressed as mean ± standard division. For antidermatophytic assay, the significance of the difference between control and test was analyzed statistically using Fisher’s exact test. Results Ethyl acetate extract of M. micrantha exhibited excellent antidermatophytic activity, followed by petroleum ether and methanolic extracts. Ethyl acetate extracts of whole plant, flowers, leaves and stem completely inhibited the growth of dermatophytes at the tested concentration of 2 mg/mL. Furthermore, ethyl acetate extracts of whole plant, leaves and flowers were fungicidal, and the percentages of trypsin inhibition exhibited were 33.73 ± 0.306, 39.0 ± 0.505 and 35.53 ± 0.503, respectively. Conclusions Since M. micrantha possesses antidermatophytic as well as anti-inflammatory activities, the plant is an excellent candidate for the development of new medicaments against dermatophytoses in traditional as well as modern medicine.
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Jyothilakshmi, M., Jyothis, M., & Latha, M. S. (2015). Antidermatophytic Activity of Mikania micrantha Kunth: An Invasive Weed. Pharmacognosy Research, 7(5S), S20–S25. https://doi.org/10.4103/0974-8490.157994