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Pharmacognosy ResearchNOW IN
Article

Evaluation of Antioxidant and Hepatoprotective Activity of Fruit Rind Extract of Garcinia dulcis (Roxburgh) Kurz

Nabajyoti Gogoi1, Ankur Gogoi1, Bijoy Neog2★, Dibyojyoti Baruah2, Khumanthem Deepak Singh3★ Corresponding author

  1. 1Centre for Biotechnology and Bioinformatics Dibrugarh University, Dibrugarh, Assam, INDIA.
  2. 2Department of Life Sciences, Plant Molecular Biology Laboratory, Dibrugarh University, Dibrugarh, Assam, INDIA.
  3. 3Department of Pharmaceutical Science, Dibrugarh University, Dibrugarh, Assam, INDIA.

CORRESPONDENCE

Bijoy Neog

Department of Life Sciences, Plant Molecular Biology Laboratory, Dibrugarh University, Dibrugarh, Assam, INDIA.

bijoyneog@dibru.ac.in

Volume 9, Issue 3 · pp. 266–272 · PUBLISHED · DOI: 10.4103/0974-8490.210330

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ABSTRACT

Background:Garciniaspp. belongs to the family Clusiaceae has been traditionally used for the treatment of many ailments including the liver damage.Garcinia dulcis found in North Eastern region of Assam; India can be a potential candidature to combat different ailments. Objective: The present work has been designed in such a way to appraisal the antioxidant and hepatoprotective activity of fruit rind extract of this plant. Materials and Methods:The antioxidant activity was investigated through the variousin vitro models, namely, 2,2-diphenyl-1-picrylhydrazine, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, nitrite oxide. Phytochemical investigation for total phenolic and flavonoids contents were carried out by standard protocol. For the evaluation of hepatoprotective activity, albino Wistar rats were divided into five groups, five animals per group and activity was determined by measuring the contents of liver function marker enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), and biochemical parameter, that is, Bilirubin and total protein. Histopathology observation of liver sections was conducted. Results: Phytochemical investigation revealed the presence of both phenolic and flavonoid groups in the extract in a significant amount. Antioxidant activity of the plant extract was observed in all models and percentage of inhibition was dose-dependent. Intoxicated with carbon tetrachloride, elevated the liver function enzymes, bilirubin, and suppressed the production of total protein. Pretreatment with the extract decreased the SGOT, SGPT, ALP, and bilirubin level significantly and increased the production level of total protein in a dose-dependent manner. The histopathological observation supported the hepatoprotective potentiality of the extract. Conclusion:The results indicate that fruit rind part of G. dulcisis nontoxic and the plant can utilize as an antioxidant source. The plant has a protective agent for liver damages and other diseases caused by free radicals.

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    Gogoi, N., Gogoi, A., Neog, B., Baruah, D., & Singh, K. D. (). Evaluation of Antioxidant and Hepatoprotective Activity of Fruit Rind Extract of Garcinia dulcis (Roxburgh) Kurz. Pharmacognosy Research, 9(3), 266–272. https://doi.org/10.4103/0974-8490.210330