Curcumin attenuates neurotoxicity induced by fl uoride: An in vivo evidence
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- 1Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India.
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Maheep Bhatnagar
Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India.
Received: 29-01-2013; Revised: 08-05-2013.
Volume 10, Issue 37 · pp. 61–65 · 2014 · DOI: 10.4103/0973-1296.126663
ABSTRACT
Background: Curcumin (Cur), an active ingredient of turmeric is known to have multiple activities, including an antioxidant property and has been suggested to be useful in treatment of several neurological diseases.Objective: To investigate the neuroprotective effects of Cur to mitigate the effect of the Fluoride (F) induced neurotoxicity in mice brain using the histological and the biochemical parameters.Materials and Methods: Exposure of mice (30 days old male) to F (120 ppm) daily for 30 days. Result and Discussion: Treatment with the F causes an increase in lipid peroxidation (LPO) and also increase in the neurodegenerative cells in the hippocampal sub-regions. Interestingly, co-treatment with Cur (30 mg/kg BW) with F (120 ppm) for 30 days results in signifi cant decreases in LPO with a concomitant decrease in neurodegeneration as compared with those treated with F alone.Conclusion: Our study reveals that Cur is useful in ameliorating degenerative effects of F in mice brain.
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Sharma, C., Suhalka, P., Sukhwal, P., Jaiswal, N., & Bhatnagar, M. (2014). Curcumin attenuates neurotoxicity induced by fl uoride: An in vivo evidence. Pharmacognosy Magazine, 10(37), 61–65. https://doi.org/10.4103/0973-1296.126663